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ATC Group: N02AA Natural opium alkaloids

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
N
Nervous system
2
N02
Analgesics
3
N02A
Opioids
4
N02AA
Natural opium alkaloids

Contents

Code
Title
N02AA01
Morphine
N02AA02
Opium
N02AA03
Hydromorphone
N02AA04
Nicomorphine
N02AA05
Oxycodone
N02AA08
Dihydrocodeine
N02AA10
Papaveretum
N02AA11
Oxymorphone
N02AA51
Morphine, combinations
N02AA55
Oxycodone, combinations
N02AA58
Dihydrocodeine, combinations
N02AA59
Codeine, combinations excl. psycholeptics
N02AA79
Codeine, combinations with psycholeptics

Active Ingredients

Chemical substance
Description
Dihydrocodeine

Dihyrodrocodeine is an opioid agonist with no antagonistic action.

Hydromorphone

Hydromorphone is an agonist of mu receptors. The pharmacological actions of hydromorphone and morphine do not differ significantly. Hydromorphone and related opioids produce their major effects on the central nervous system and bowel. Hydromorphone is indicated for the relief of severe pain in cancer.

Morphine

Morphine is a narcotic analgesic obtained from opium. Morphine acts as an agonist at opiate receptors in the CNS particularly Mu and to a lesser extent Kappa receptors. Mu receptors are thought to mediate supraspinal analgesia, respiratory depression and euphoria, and Kappa receptors, spinal analgesia, miosis and sedation.

Nicomorphine

Nicomorphine is the 3,6-dinicotinate ester of morphine. Nicomorphine is a strong opioid agonist analgesic two to three times as potent as morphine with a side effect profile similar to that of dihydromorphine, morphine, and diamorphine. The 3,6-diesters of morphine are drugs with more rapid and complete central nervous system penetration due to increased lipid solubility and other structural considerations.

Opium

Opium alkaloids (opioids and isoquinoline derivatives) induce constipation, euphoria, analgesia and sedation dependent on the dose and derivative. The constipating effect is caused by inhibition of the intestines' peristalsis.

Oxycodone

Oxycodone is a full opioid agonist with no antagonist properties. It has an affinity for kappa, mu and delta opioid receptors in the brain and spinal cord. Oxycodone is similar to morphine in its action. The therapeutic effect is mainly analgesic, anxiolytic, antitussive and sedative.

Monographs

Monograph
Type
Country
DILAUDID Solution for injection
MPI, US: SPL/PLR
US
KADIAN Capsule extended-release
MPI, US: SPL/PLR
US
LYNLOR Capsule, hard
MPI, EU: SmPC
UK
MORPHGESIC Controlled release tablet
MPI, EU: SmPC
UK
MS CONTIN Tablet
MPI, US: SPL/PLR
US
MST CONTINUS Prolonged release granules for oral suspension
MPI, EU: SmPC
UK
MST CONTINUS Prolonged-release tablet
MPI, EU: SmPC
UK
OXYACT Film-coated tablet
MPI, EU: SmPC
UK
OXYCODONE HYDROCHLORIDE Capsule
MPI, US: SPL/PLR
US
OXYCODONE HYDROCHLORIDE Solution for injection or infusion
MPI, EU: SmPC
UK
OXYCONTIN Extended-release tablet / Film coated tablet
MPI, US: SPL/PLR
US
OXYNORM Capsule, hard
MPI, EU: SmPC
UK
OXYNORM Solution for injection or infusion
MPI, EU: SmPC
UK
SEVREDOL Film-coated tablet
MPI, EU: SmPC
UK