ATC Group: P01C Agents against leishmaniasis and trypanosomiasis

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of P01C in the ATC hierarchy

Level Code Title
1 P Antiparasitic products, insecticides and repellents
2 P01 Antiprotozoals
3 P01C Agents against leishmaniasis and trypanosomiasis

Group P01C contents

Code Title
P01CA Nitroimidazole derivatives
P01CB Antimony compounds
P01CC Nitrofuran derivatives
P01CD Arsenic compounds
P01CX Other agents against leishmaniasis and trypanosomiasis

Active ingredients in P01C

Active Ingredient Description

Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme involved in the production of the hair shaft by the hair follicle. Eflornithine has been shown to reduce the rate of hair growth.


Miltefosine has a marked direct antileishmanial activity in vitro and in animal models. Leishmania donovani was the most sensitive species in promastigote and amastigote test systems.


Nifurtimox is an antiprotozoal drug. It is used in pediatric patients for the treatment of Chagas disease (American Trypanosomiasis) caused by Trypanosoma cruzi. Nifurtimox exposure-response relationships and the time course of pharmacodynamics response are unknown.


Pentamidine isetionate is an aromatic diamine. It is an antiprotozoal agent which acts by interfering with DNA and folate transformation, and by the inhibition of RNA and protein synthesis.

Sodium stibogluconate

Related product monographs

Title Information Source Document Type  
GASTROGRAFIN Gastroenteral solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
PENTACARINAT Powder for reconstitution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC