Active Ingredient: Esomeprazole
In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori and healing of Helicobacter pylori associated duodenal ulcer.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 20 milligrams esomeprazole, 2 times daily, over the duration of 7 days.
When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents. The treatment should be supervised by a specialist.
The posology recommendation is:
| Weight | Posology |
|---|---|
| 30-40 kg | Combination with two antibiotics: esomeprazole 20 mg, amoxicillin 750 mg and clarithromycin 7.5 mg/kg body weight are all administered together twice daily for one week. |
| >40 kg|Combination with two antibiotics: esomeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg are alladministered together twice daily for one week.
For:
Oral, 20 milligrams esomeprazole, 2 times daily, over the duration of 7 days.
For:
Regimen A, in the case that patient age in years is > 4 and patient weight is < 30 kg :
Oral, 10 milligrams esomeprazole, 2 times daily, over the duration of 7 days.
Regimen B, in the case that patient age in years is > 4 and patient weight is ≥ 30 kg and patient weight is < 40 kg :
Oral, 20 milligrams esomeprazole, 2 times daily, over the duration of 7 days.
Regimen C, in the case that patient age in years is > 4 and patient weight is > 40 kg :
Oral, 20 milligrams esomeprazole, 2 times daily, over the duration of 7 days.
When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents. The treatment should be supervised by a specialist.
The posology recommendation is:
| Weight | Posology |
|---|---|
| <30 kg | Combination with two antibiotics: esomeprazole 10 mg, amoxicillin 25 mg/kg body weight and clarithromycin 7.5 mg/kg body weight are all administered together twice daily for one week. |
| 30-40 kg | Combination with two antibiotics: esomeprazole 20 mg, amoxicillin 750 mg and clarithromycin 7.5 mg/kg body weight are all administered together twice daily for one week. |
| >40 kg | Combination with two antibiotics: esomeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg are all administered together twice daily for one week. |
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