For this indication, competent medicine agencies globally authorize below treatments:
0.1 - 0.2 mg per kg of body weight
From 0.1 To 0.2 mg per kg of body weight once every day
Used as a single agent the usual dosage is 0.1-0.2 mg/kg/day for 4-8 weeks initially, maintenance therapy is then given either by a reduced daily dosage or intermittent courses of treatment.
Chlorambucil is useful in the management of patients with advanced diffuse lymphocytic lymphoma and those who have relapsed after radiotherapy. There is no significant difference in the overall response rate obtained with chlorambucil as a single agent and combination chemotherapy in patients with advanced non-Hodgkin’s lymphocytic lymphoma.
Chlorambucil may be used in the management of non Hodgkin’s disease in children. The dosage regimes are similar to those used in adults.
Chlorambucil is administered orally and should be taken daily on an empty stomach (at least one hour before meals or three hours after meals).