Chemical formula: C₁₄H₁₉Cl₂NO₂ Molecular mass: 304.212 g/mol PubChem compound: 2708
Chlorambucil is an aromatic nitrogen mustard derivative which acts as a bifunctional alkylating agent. In addition to interference with DNA replication, chlorambucil induces cellular apoptosis via the accumulation of cytosolic p53 and subsequent activation of an apoptosis promoter.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01AA02 | Chlorambucil | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AA Nitrogen mustard analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| CHLORAMBUCIL Film-coated tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| LEUKERAN Tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Chlorambucil is an active ingredient of these brands:
United States (US)Australia (AU)Brazil (BR)Canada (CA)Estonia (EE)Finland (FI)France (FR)Hong Kong (HK)Ireland (IE)Israel (IL)Malta (MT)Mexico (MX)Netherlands (NL)New Zealand (NZ)Poland (PL)Romania (RO)Singapore (SG)Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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