For this indication, competent medicine agencies globally authorize below treatments:
0.2 - 0.2 mg per kg of body weight
From 0.2 To 0.2 mg per kg of body weight once every day
Used as a single agent in the palliative treatment of advanced disease a typical dosage is 0.2 mg/kg/day for 4-8 weeks. Chlorambucil is usually included in combination therapy and a number of regimes have been used. Chlorambucil has been used as an alternative to nitrogen mustard with a reduction in toxicity but similar therapeutic results.
Chlorambucil may be used in the management of Hodgkin’s disease in children. The dosage regimes are similar to those used in adults.
Chlorambucil is administered orally and should be taken daily on an empty stomach (at least one hour before meals or three hours after meals).