Hodgkin's disease

Indication for Chlorambucil

Population group: Suitable for both men and women, only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

0.2 mg/kg once daily

Route of admnistration


Defined daily dose

0.2 - 0.2 mg per kg of body weight

Dosage regimen

From 0.2 To 0.2 mg per kg of body weight once every day

Detailed description


Used as a single agent in the palliative treatment of advanced disease a typical dosage is 0.2 mg/kg/day for 4-8 weeks. Chlorambucil is usually included in combination therapy and a number of regimes have been used. Chlorambucil has been used as an alternative to nitrogen mustard with a reduction in toxicity but similar therapeutic results.

Paediatric population

Chlorambucil may be used in the management of Hodgkin’s disease in children. The dosage regimes are similar to those used in adults.

Dosage considerations

Chlorambucil is administered orally and should be taken daily on an empty stomach (at least one hour before meals or three hours after meals).

Active ingredient

Chlorambucil is an aromatic nitrogen mustard derivative which acts as a bifunctional alkylating agent. In addition to interference with DNA replication, chlorambucil induces cellular apoptosis via the accumulation of cytosolic p53 and subsequent activation of an apoptosis promoter.

Read more about Chlorambucil

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