Zollinger-Ellison syndrome

Active Ingredient: Esomeprazole

Indication for Esomeprazole

Population group: only adults (18 years old or older)

Treatment of Zollinger Ellison Syndrome.

For this indication, competent medicine agencies globally authorize below treatments:

80-160 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

80 - 160 mg

Dosage regimen

From 40 To 80 mg 2 time(s) per day every day

Loading dose

80 mg

Detailed description

The recommended initial dosage is esomeprazole 40 mg twice daily. The dosage should then be individually adjusted and treatment continued as long as clinically indicated. Based on the clinical data available, the majority of patients can be controlled on doses between 80 to 160 mg esomeprazole daily. With doses above 80 mg daily, the dose should be divided and given twice daily.

Active ingredient

Esomeprazole

Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+ K+ -ATPase – the acid pump and inhibits both basal and stimulated acid secretion.

Read more about Esomeprazole

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