Prevention of rebleeding following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers

Active Ingredient: Esomeprazole

Indication for Esomeprazole

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Preventive action

For this indication, competent medicine agencies globally authorize below treatments:

80 mg as a bolus infusion, followed by a continuous intravenous infusion of 8 mg/h given over 3 day

For:

Dosage regimens

Intravenous, 80 milligrams esomeprazole, one dose. Afterwards, intravenous, 8 milligrams esomeprazole, once hourly, over the duration of 3 days.

Detailed description

Following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers, 80 mg should be administered as a bolus infusion over 30 minutes, followed by a continuous intravenous infusion of 8 mg/h given over 3 days (72 hours).

Dosage considerations

Continuous intravenous infusion of 8 mg/h given over 3 days (72 hours).

Active ingredient

Esomeprazole

Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+K+-ATPase – the acid pump and inhibits both basal and stimulated acid secretion.

Read more about Esomeprazole

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