Active Ingredient: Esomeprazole
Symptomatic treatment of gastroesophageal reflux disease (GERD).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 20 milligrams esomeprazole, once daily.
20 mg once daily in patients without esophagitis. If symptom control has not been achieved after 4 weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using 20 mg once daily. An on demand regimen taking 20 mg once daily, when needed, can be used.
For:
Intravenous, 20 milligrams esomeprazole, once daily.
Patients who cannot take oral medication may be treated parenterally with 20–40 mg once daily. Patients treated symptomatically for reflux disease should be treated with 20 mg once daily.
20 mg dose: Should be given as an intravenous injection over a period of at least 3 minutes. Any unused solution should be discarded.
20 mg dose: Should be given as an intravenous infusion over a period of 10 to 30 minutes. Any unused solution should be discarded.
For:
In the case that patient weight is ≥ 10 kg :
Oral, 10 milligrams esomeprazole, once daily, over the duration of up to 8 weeks.
Symptomatic treatment of gastroesophageal reflux disease (GERD): 10 mg once daily for up to 8 weeks.
The experience of treatment with esomeprazole in infants <1 year is limited and treatment is therefore not recommended.
For:
Regimen A, in the case that patient age in years is ≥ 1 and patient age in years is ≤ 11 :
Intravenous, 10 milligrams esomeprazole, once daily.
Regimen B, in the case that patient age in years is ≥ 12 :
Intravenous, 20 milligrams esomeprazole, once daily.
Patients who cannot take oral medication may be treated parenterally once daily, as a part of a full treatment period for GERD (see doses in table below).
Usually the intravenous treatment duration should be short and transfer to oral treatment should be made as soon as possible.
Recommended intravenous doses of esomeprazole:
| Age group | Symptomatic treatment of GERD |
|---|---|
| 1-11 Years | 10 mg once daily |
| 12-18 Years | 20 mg once daily |
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