Gastroesophageal reflux disease (GERD)

Active Ingredient: Esomeprazole

Indication for Esomeprazole

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Symptomatic treatment of gastroesophageal reflux disease (GERD).

For this indication, competent medicine agencies globally authorize below treatments:

20 mg once daily

Route of admnistration

Oral

Defined daily dose

20 - 20 mg

Dosage regimen

From 20 To 20 mg once every day

Loading dose

20 mg

Detailed description

20 mg once daily in patients without esophagitis. If symptom control has not been achieved after 4 weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using 20 mg once daily. An on demand regimen taking 20 mg once daily, when needed, can be used.

20 mg once daily

Route of admnistration

Intravenous

Defined daily dose

20 - 20 mg

Dosage regimen

From 20 To 20 mg once every day

Detailed description

Patients who cannot take oral medication may be treated parenterally with 20–40 mg once daily. Patients treated symptomatically for reflux disease should be treated with 20 mg once daily.

Dosage considerations

Injection

20 mg dose: Should be given as an intravenous injection over a period of at least 3 minutes. Any unused solution should be discarded.

Infusion

20 mg dose: Should be given as an intravenous infusion over a period of 10 to 30 minutes. Any unused solution should be discarded.

Active ingredient

Esomeprazole

Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+ K+ -ATPase – the acid pump and inhibits both basal and stimulated acid secretion.

Read more about Esomeprazole

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