Active Ingredient: Esomeprazole
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 40 milligrams esomeprazole, once daily.
Patients who cannot take oral medication may be treated parenterally with 20–40 mg once daily. Patients with reflux esophagitis should be treated with 40 mg once daily.
40 mg dose: Should be given as an intravenous injection over a period of at least 3 minutes.
40 mg dose: The reconstituted solution should be given as an intravenous infusion over a period of 10 to 30 minutes.
For:
Oral, 40 milligrams esomeprazole, once daily, over the duration of 4 weeks.
40 mg once daily for 4 weeks. An additional 4 weeks treatment is recommended for patients in whom esophagitis has not healed or who have persistent symptoms.
For:
Regimen A, in the case that patient age in years is ≥ 1 and patient age in years is ≤ 11 and patient weight is < 20 kg :
Intravenous, 10 milligrams esomeprazole, once daily.
Regimen B, in the case that patient age in years is ≥ 1 and patient age in years is ≤ 11 and patient weight is ≥ 20 kg :
Intravenous, between 10 milligrams esomeprazole and 20 milligrams esomeprazole, once daily.
Regimen C, in the case that patient age in years is ≥ 12 :
Intravenous, 40 milligrams esomeprazole, once daily.
Patients who cannot take oral medication may be treated parenterally once daily, as a part of a full treatment period for GERD (see doses in table below).
Usually the intravenous treatment duration should be short and transfer to oral treatment should be made as soon as possible.
Recommended intravenous doses of esomeprazole:
| Age group | Treatment of erosive reflux esophagitis |
|---|---|
| 1-11 Years | Weight <20 kg: 10 mg once daily |
| Weight ≥20 kg: 10 mg or 20 mg once daily | |
| 12-18 Years | 40 mg once daily |
For:
Regimen A, in the case that patient weight is ≥ 10 kg and patient weight is < 20 kg :
Oral, 10 milligrams esomeprazole, once daily, over the duration of 8 weeks.
Regimen B, in the case that patient weight is ≥ 20 kg :
Oral, between 10 milligrams esomeprazole and 20 milligrams esomeprazole, once daily, over the duration of 8 weeks.
Treatment of endoscopically proven erosive reflux esophagitis:
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