Erosive reflux esophagitis

Active Ingredient: Esomeprazole

Indication for Esomeprazole

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Treatment of erosive reflux esophagitis.

For this indication, competent medicine agencies globally authorize below treatments:

40 mg once daily

Route of admnistration

Intravenous

Defined daily dose

40 - 40 mg

Dosage regimen

From 40 To 40 mg once every day

Detailed description

Patients who cannot take oral medication may be treated parenterally with 20–40 mg once daily. Patients with reflux esophagitis should be treated with 40 mg once daily.

Dosage considerations

Injection

40 mg dose: Should be given as an intravenous injection over a period of at least 3 minutes.

Infusion

40 mg dose: The reconstituted solution should be given as an intravenous infusion over a period of 10 to 30 minutes.

40 mg once daily

Route of admnistration

Oral

Defined daily dose

40 - 40 mg

Dosage regimen

From 40 To 40 mg once every day

Loading dose

40 mg

Detailed description

40 mg once daily for 4 weeks. An additional 4 weeks treatment is recommended for patients in whom esophagitis has not healed or who have persistent symptoms.

Active ingredient

Esomeprazole

Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+ K+ -ATPase – the acid pump and inhibits both basal and stimulated acid secretion.

Read more about Esomeprazole

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