Erosive reflux esophagitis

Active Ingredient: Esomeprazole

Indication for Esomeprazole

Population group: only children (1 year - 12 years old)

Treatment of endoscopically proven erosive reflux esophagitis.

For this indication, competent medicine agencies globally authorize below treatments:

10-20 mg once daily

Route of admnistration

Oral

Defined daily dose

10 - 20 mg

Dosage regimen

From 10 To 20 mg once every day

Detailed description

Weight ≥10 - <20 kg: 10 mg once daily for 8 weeks.

Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks.

10-20 mg once daily

Route of admnistration

Intravenous

Defined daily dose

10 - 20 mg

Dosage regimen

From 10 To 20 mg once every day

Detailed description

Recommended intravenous doses of esomeprazole:

Age groupTreatment of erosive reflux esophagitisSymptomatic treatment of GERD
1-11 YearsWeight <20 kg: 10 mg once daily10 mg once daily
Weight ≥20 kg: 10 mg or 20 mg once daily
12-18 Years40 mg once daily20 mg once daily

Dosage considerations

Injection

20 mg dose: Should be given as an intravenous injection over a period of at least 3 minutes. Any unused solution should be discarded.

10 mg dose: Should be given as an intravenous injection over a period of at least 3 minutes. Any unused solution should be discarded.

Infusion

20 mg dose: Should be given as an intravenous infusion over a period of 10 to 30 minutes. Any unused solution should be discarded.

10 mg dose: Should be given as an intravenous infusion over a period of 10 to 30 minutes. Any unused solution should be discarded.

Active ingredient

Esomeprazole

Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+ K+ -ATPase – the acid pump and inhibits both basal and stimulated acid secretion.

Read more about Esomeprazole

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