CARE CODEINE Oral liquid Ref.[108795] Active ingredients: Codeine

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2014  Publisher: Thornton & Ross Ltd., Linthwaite, Huddersfield, HD7 5QH, United Kingdom

5.1. Pharmacodynamic properties

RO5DA04 – Cough suppressants, excl. combinations with expectorants – opium alkaloids and derivatives

Galcodine contains codeine phosphate which is an opiate with analgesic, anti-diarrhoeal and cough suppressant activities.

Codeine is a centrally acting weak analgesic. Codeine exerts its effect through ยต opioid receptors, although codeine has low affinity for these receptors, and its analgesic effect is due to its conversion to morphine. Codeine, particularly in combination with other analgesics such as paracetamol, has been shown to be effective in acute nociceptive pain.

5.2. Pharmacokinetic properties

None stated.

5.3. Preclinical safety data

None stated.

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