CARE CODEINE Oral liquid Ref.[108795] Active ingredients: Codeine

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2014  Publisher: Thornton & Ross Ltd., Linthwaite, Huddersfield, HD7 5QH, United Kingdom

4.1. Therapeutic indications

Codeine is indicated in adults for the relief of an unproductive dry cough.

4.2. Posology and method of administration

For oral administration.

Adult

One 5ml spoonful four times daily.

Elderly

Should be used with caution; a reduced dose can be recommended by a doctor.

Paediatric population

Codeine should not be used for the treatment of children under the age of 18 years.

4.9. Overdose

The effects in overdosage will be potentiated by simultaneous ingestion of alcohol and psychotropic drugs.

Symptoms

Central nervous system depression, including respiratory depression, may develop but is unlikely to be severe unless other sedative agents have been co-ingested, including alcohol, or the overdose is very large. The pupils may be pinpoint in size; nausea and vomiting are common. Hypotension and tachycardia are possible but unlikely.

Management

This should include general symptomatic and supportive measures including a clear airway and monitoring of vital signs until stable. Consider activated charcoal if an adult presents within one hour of ingestion of more than 350 mg or if more than 2.5 mg/kg (adults and children) has been ingested.

Give naloxone if coma or respiratory depression is present. Naloxone is a competitive antagonist and has a short halflife so large and repeated doses may be required in a seriously poisoned patient. Observe for at least four hours after ingestion, or eight hours if a sustained release preparation has been taken.

6.3. Shelf life

Two years from the date of manufacture.

6.4. Special precautions for storage

Do not store above 25°C.

6.5. Nature and contents of container

Amber HDPE 2 litre Winchester with a white tamper evident polyethylene cap.

200ml Amber glass bottle with a white 28mm child-resistant tamper evident cap with EPE/Saranex Liner.

6.6. Special precautions for disposal and other handling

None stated.

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