Active ingredients: Digoxin
Lanoxin 125 Tablets.
Digoxin Ph Eur 0.125 mg/tablet
Digoxin increases contractility of the myocardium by direct activity. The primary action of digoxin is specifically to inhibit adenosine triphosphatase, and thus sodium-potassium (Na+ - K+) exchange activity, the altered ionic distribution across the membrane resulting in an augmented calcium ion influx and thus an increase in the availability of calcium at the time of excitation-contraction coupling. The potency of digoxin may therefore appear considerably enhanced when the extracellular potassium concentration is low, with hyperkalaemia having the opposite effect.
Lactose Ph Eur
Starches Ph Eur
Hydrolysed Starch HSE
Magnesium Stearate Ph Eur
Amber glass bottle with low-density polyethylene snap-fit closure
Pack sizes: 28, 50, 500 tablets
Amber glass bottle with a clic-loc child resistant closure
Pack size: 56 tablets
White opaque PVC/aluminium foil blister
Pack sizes: 30, 60, 90, 120 tablets
Not all pack sizes may be marketed.
Aspen Pharma Trading Limited
12/13 Exchange Place
24 April 2003