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Lanoxin 125 Tablets (2012)

Active ingredients: Digoxin

Product Name and Form

Lanoxin 125 Tablets.

Pharmaceutical form

Tablet.

Qualitative and Quantitative Composition

Digoxin Ph Eur 0.125 mg/tablet

Chemical substance
Description
Digoxin

Digoxin increases contractility of the myocardium by direct activity. The primary action of digoxin is specifically to inhibit adenosine triphosphatase, and thus sodium-potassium (Na+ - K+) exchange activity, the altered ionic distribution across the membrane resulting in an augmented calcium ion influx and thus an increase in the availability of calcium at the time of excitation-contraction coupling. The potency of digoxin may therefore appear considerably enhanced when the extracellular potassium concentration is low, with hyperkalaemia having the opposite effect.

List of excipients

Lactose Ph Eur
Starches Ph Eur
Hydrolysed Starch HSE
Magnesium Stearate Ph Eur

Pack sizes and Marketing

Amber glass bottle with low-density polyethylene snap-fit closure

Pack sizes: 28, 50, 500 tablets

Amber glass bottle with a clic-loc child resistant closure

Pack size: 56 tablets

White opaque PVC/aluminium foil blister

Pack sizes: 30, 60, 90, 120 tablets

Not all pack sizes may be marketed.

Marketing authorization holder
Authorization dates

Aspen Pharma Trading Limited
12/13 Exchange Place
I.F.S.C
Dublin 1
Ireland

24 April 2003

Marketing authorization number:

PL 39699/0009