Source: Υπουργείο Υγείας (CY) Revision Year: 2019 Publisher: Farco-Pharma GmbH, Gereonsmühlengasse 1‑11, 50670 Köln, Germany, Tel: ++49 221 594061, Fax: ++49 221 593614
Pharmacotherapeutic group: Anaesthetics, local
ATC code: N01BB02
The anaesthetic ingredient of Instillagel is lidocaine, which stabilizes neuronal membranes and prevents initiation and conduction of nerve impulses, thus effecting local anaesthetic action.
Chlorhexidine and methyl and propyl hydroxybenzoates have antiseptic properties.
After the product’s application to mucous membranes, lidocaine is absorbed, but its blood concentrations after the instillation of doses of up to 800mg into the urethra remain in the low range, below toxic levels. The metabolism of lidocaine takes place in the liver and unchanged drugs is excreted renally.
Very small amounts of chlorhexidine may be absorbed. Chlorhexidine is eliminated almost unchanged although it is hardly absorbed even after high oral doses. Although parahydroxybenzoates can be absorbed from mucous membranes, they are rapidly eliminated and do not accumulate. The parahydroxybenzoates are excreted in the form of parahydroxybenzoic acid.
Not applicable.
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