Chlorhexidine Other names: Decanoylacetaldehyde Sodium Sulfide

Chemical formula: C₂₂H₃₀Cl₂N₁₀  Molecular mass: 505.447 g/mol  PubChem compound: 9552079

Active ingredient description

Chlorhexidine is an antimicrobial agent, active against a broad spectrum of Gram-positive and Gram-negative organisms, yeasts, fungi, opportunistic anaerobes and aerobes. Chlorhexidine is mainly a “membrane-acting” agent that destroys the outer membrane of the bacteria. It is inactive on bacterial spores unless the temperatures are high.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A01AB03 Chlorhexidine A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment
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B05CA02 Chlorhexidine B Blood and blood forming organs → B05 Blood substitutes and perfusion solutions → B05C Irrigating solutions → B05CA Antiinfectives
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D08AC02 Chlorhexidine D Dermatologicals → D08 Antiseptics and disinfectants → D08A Antiseptics and disinfectants → D08AC Biguanides and amidines
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D09AA12 Chlorhexidine D Dermatologicals → D09 Medicated dressings → D09A Medicated dressings → D09AA Medicated dressings with antiinfectives
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R02AA05 Chlorhexidine R Respiratory system → R02 Throat preparations → R02A Throat preparations → R02AA Antiseptics
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S01AX09 Chlorhexidine S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AX Other antiinfectives
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S02AA09 Chlorhexidine S Sensory organs → S02 Otologicals → S02A Antiinfectives → S02AA Antiinfectives
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S03AA04 Chlorhexidine S Sensory organs → S03 Ophthalmological and otological preparations → S03A Antiinfectives → S03AA Antiinfectives
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Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ACRIFLEX Cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
PAROEX Oral rinse FDA, National Drug Code (US) MPI, US: SPL/Old
CORSODYL ORIGINAL Mouthwash Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 18472-51-0
CAS Substance: 55-56-1
DrugBank Drug: DB00878
KEGG Drug: D07668
PubChem Compound: 9552079
RxNorm Ingredient: 2358
SNOMED-CT Concept: 373568007
Chlorhexidine (substance)
UNII Identifier: R4KO0DY52L
CHLORHEXIDINE

Medicines

Chlorhexidine is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

  • (combination) ANGAL as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) ANGAL S as CHLORHEXIDINE GLUCONATE
  • (combination) BEPANTHEN PLUS as CHLORHEXIDINE HYDROCHLORIDE

Cyprus (CY)

  • (combination) DRILL as Chlorhexidine digluconate
  • (combination) INSTILLAGEL as Chlorhexidine digluconate
  • (combination) NYSTALOCAL

Ecuador (EC)

  • ANTISEK as CHLORHEXIDINE GLUCONATE
  • BONCIDA as CHLORHEXIDINE GLUCONATE
  • ENCIDENT as CHLORHEXIDINE GLUCONATE
  • LIRAVLON as CHLORHEXIDINE GLUCONATE
  • MERTHIOPARA as CHLORHEXIDINE GLUCONATE
  • PROEXIDIN as CHLORHEXIDINE GLUCONATE
  • SEPTIGEN as CHLORHEXIDINE GLUCONATE

  • (combination) BUCAGEL as CHLORHEXIDINE GLUCONATE
  • (combination) BUCAGEL NF as CHLORHEXIDINE GLUCONATE
  • (combination) GERMIDAL as CHLORHEXIDINE GLUCONATE
  • (combination) ORACOL as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) SOLUPREP as CHLORHEXIDINE GLUCONATE
  • (combination) TURIVLON as CHLORHEXIDINE GLUCONATE

Estonia (EE)

Finland (FI)

  • CORSODYL as CHLORHEXIDINE GLUCONATE
  • TRAVAHEX as CHLORHEXIDINE ACETATE

  • (combination) CHLORAPREP as CHLORHEXIDINE GLUCONATE
  • (combination) DUOCORT as CHLORHEXIDINE GLUCONATE
  • (combination) SIBICORT as CHLORHEXIDINE GLUCONATE
  • (combination) TONCILS as CHLORHEXIDINE HYDROCHLORIDE

France (FR)

Hong Kong (HK)

Ireland (IE)

  • CORSODYL as CHLORHEXIDINE GLUCONATE
  • HYDREX as CHLORHEXIDINE GLUCONATE
  • PERIOCHIP as CHLORHEXIDINE GLUCONATE
  • PREVORA as CHLORHEXIDINE ACETATE

  • (combination) BEPANTISEPTIC as CHLORHEXIDINE GLUCONATE
  • (combination) CHLORAPREP as CHLORHEXIDINE GLUCONATE
  • (combination) HEXIPREP as CHLORHEXIDINE GLUCONATE
  • (combination) INSTILLAGEL as Chlorhexidine digluconate
  • (combination) NASEPTIN as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) SAVLON as CHLORHEXIDINE GLUCONATE
  • (combination) SOLUPREP as CHLORHEXIDINE GLUCONATE

Israel (IL)

  • CORSODYL as CHLORHEXIDINE GLUCONATE
  • HEXIDYL as CHLORHEXIDINE GLUCONATE
  • SEPTAL as CHLORHEXIDINE GLUCONATE
  • TARODENT as CHLORHEXIDINE GLUCONATE

  • (combination) BEPANTHEN PLUS as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) CATHEJELL LIDOCAINE as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) CETRIN as CHLORHEXIDINE GLUCONATE
  • (combination) INSTILLAGEL as Chlorhexidine digluconate
  • (combination) MERFEN as CHLORHEXIDINE GLUCONATE
  • (combination) SAVIOR as CHLORHEXIDINE GLUCONATE
  • (combination) VITA-MERFEN as CHLORHEXIDINE GLUCONATE

Japan (JP)

Lithuania (LT)

  • (combination) BEPANTHEN PLUS as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) CATHEJELL L as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) DERMOBACTER as CHLORHEXIDINE GLUCONATE
  • (combination) HEXORALETTEN N as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) SEBIDIN as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) TRACHISAN as CHLORHEXIDINE GLUCONATE

Malta (MT)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

  • PERIOCHIP as CHLORHEXIDINE GLUCONATE

  • (combination) HORF as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) SILVAZINE as Chlorhexidine digluconate
  • (combination) SILVIN as Chlorhexidine digluconate
  • (combination) SOOV as CHLORHEXIDINE GLUCONATE

South Africa (ZA)

  • BACTIGRAS as CHLORHEXIDINE ACETATE
  • BIOTAINE as CHLORHEXIDINE GLUCONATE
  • CORSODYL as CHLORHEXIDINE GLUCONATE
  • EXITANE as CHLORHEXIDINE GLUCONATE
  • HEXIDIN as CHLORHEXIDINE GLUCONATE
  • HIBIDIL as CHLORHEXIDINE GLUCONATE
  • HYDREX as CHLORHEXIDINE GLUCONATE
  • OROSEPT as CHLORHEXIDINE GLUCONATE
  • STERIPREP as CHLORHEXIDINE GLUCONATE
  • STERISCRUB as CHLORHEXIDINE GLUCONATE
  • STERISOL as CHLORHEXIDINE GLUCONATE

  • (combination) BACTIZIP as CHLORHEXIDINE GLUCONATE
  • (combination) BACTRAZINE C as CHLORHEXIDINE GLUCONATE
  • (combination) CATHEJELL LIDOCAINE as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) CETIDINE as CHLORHEXIDINE GLUCONATE
  • (combination) CETROL as CHLORHEXIDINE GLUCONATE
  • (combination) ENDOSTIL as CHLORHEXIDINE GLUCONATE
  • (combination) FLAMAZINE C as CHLORHEXIDINE GLUCONATE
  • (combination) HIBICET as CHLORHEXIDINE GLUCONATE
  • (combination) OROCHLOR as CHLORHEXIDINE GLUCONATE
  • (combination) OROFLAM as CHLORHEXIDINE GLUCONATE
  • (combination) SAVLON as CHLORHEXIDINE GLUCONATE
  • (combination) THROFLAM-CO as CHLORHEXIDINE GLUCONATE

Spain (ES)

  • BUCOSPRAY as CHLORHEXIDINE GLUCONATE
  • CLORXIL as CHLORHEXIDINE GLUCONATE
  • CRISTALMINA as CHLORHEXIDINE GLUCONATE
  • DERATIN as CHLORHEXIDINE HYDROCHLORIDE
  • FURASEPTIC as CHLORHEXIDINE GLUCONATE
  • HIBISCRUB as CHLORHEXIDINE GLUCONATE
  • MENALMINA as CHLORHEXIDINE GLUCONATE
  • NORMOSEPT as CHLORHEXIDINE GLUCONATE

  • (combination) ANESTEFARIN as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) ANGILEPTOL as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) ANGINOCOM as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) APOGAR as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) BUCOMETASANA as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) CHLORAPREP as CHLORHEXIDINE GLUCONATE
  • (combination) DERATIN COMPLEX as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) FARBUCAL as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) FARINGESIC as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) INTERDOL as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) LIZIPAINA as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) MASTIOL as CHLORHEXIDINE ACETATE
  • (combination) MENALCOL as CHLORHEXIDINE GLUCONATE

Tunisia (TN)

Turkey (TR)

  • (combination) ANDOREX as CHLORHEXIDINE GLUCONATE
  • (combination) ANZIBEL as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) BENPAIN TRIO as CHLORHEXIDINE GLUCONATE
  • (combination) BEPANTHEN PLUS as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) CLIORO as CHLORHEXIDINE GLUCONATE
  • (combination) CLODER PLUS as CHLORHEXIDINE GLUCONATE
  • (combination) ENMIKS as CHLORHEXIDINE GLUCONATE
  • (combination) FARDOBEN as CHLORHEXIDINE GLUCONATE
  • (combination) FARHEX FORTE as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) GERAKS as CHLORHEXIDINE GLUCONATE
  • (combination) GERAL as CHLORHEXIDINE GLUCONATE
  • (combination) HEKSOBEN as CHLORHEXIDINE GLUCONATE
  • (combination) HEXADAMIN as CHLORHEXIDINE GLUCONATE
  • (combination) HEXINAT as CHLORHEXIDINE GLUCONATE
  • (combination) HIDROX PLUS as CHLORHEXIDINE HYDROCHLORIDE
  • (combination) KLODAMIN as CHLORHEXIDINE GLUCONATE
  • (combination) KLOREMIN as CHLORHEXIDINE GLUCONATE
  • (combination) KLORHEX PLUS as CHLORHEXIDINE GLUCONATE
  • (combination) KLORMERDAMIN as CHLORHEXIDINE GLUCONATE
  • (combination) KLOROBEN as CHLORHEXIDINE GLUCONATE
  • (combination) MAJEZIK PLUS as CHLORHEXIDINE GLUCONATE
  • (combination) ORASEPT PLUS as CHLORHEXIDINE GLUCONATE
  • (combination) OROHEKS PLUS as CHLORHEXIDINE GLUCONATE
  • (combination) SAVSID as CHLORHEXIDINE GLUCONATE
  • (combination) SEPTIX as CHLORHEXIDINE GLUCONATE
  • (combination) SEPTONAT as CHLORHEXIDINE GLUCONATE
  • (combination) SOLUTEM
  • (combination) TANFLEX PLUS
  • (combination) TANTUM VERDE DUO as CHLORHEXIDINE GLUCONATE
  • (combination) USYEX as CHLORHEXIDINE GLUCONATE

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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