Source: Registered Drug Product Database (NG) Publisher: Krishat Pharma Industries Limited, KM 15, Lagos-Ibadan Expressway, Ibadan, Oyo State, NIGERIA, Email: info@krishatpharma.com
It produces its antihistamine action by competitively blocking H1 receptors. It binds to the H1 receptors present in the smooth muscles of the gastrointestinal tract, bronchi, large blood vessels and uterus and inhibit Histamine induced allergic symptoms. They do not inhibit the release of Histamine.
Central antimuscarinic actions of antihistamines are responsible for these effects of Diphenhydramine.
Acetyl choline receptor antagonists are used for the treatment of Parkinsonism. Diphenhydramine reduces the unbalanced cholinergic activity in striatum of parkinsonian patients.
Diphenhydramine suppresses the cough reflex by a direct effect on the cough centre.
Diphenhydramine is used in migraine due to its sedative as well as antiemetic actions.
It is well absorbed after oral administration.
Diphenhydramine is widely distributed in the body including CNS in protein bound form.
It is extensively metabolised in the liver.
Excreted primarily in urine.
None.
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