Source: Registered Drug Product Database (NG) Revision Year: 2025 Publisher: SAM PHARMACEUTICALS LIMITED., 2, WESTERN RESERVOIR ROAD, ILORIN, KWARA STATE, NIGERIA, 08057075266, sampharmaceuticalltd@gmail.com
Pharmacotherapeutic group: Corticosteroids for systemic use
Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.
Glucortocoids cause profound and varied metabolic effects. In addition, they modify the body’s immune responses to diverse stimuli.
Prednisolone is rapidly and apparently almost completely absorbed after oral administration; it reaches peak plasma concentrations after 1-3 hours. There is however wide inter-subject variation suggesting impaired absorption in some individuals. Plasma half-life is about 3 hours in adults and somewhat less in children, Its initial absorption, but not its overall bioavailability, is affected by food. Prednisolone has a biological half-life lasting several hours, making it suitable for alternate-day administration regimens.
Prednisolone is excreted in the urine as free and conjugated metabolites, together with small amounts of unchanged prednisolone.
Significant differences in the pharmacokinetics of prednisolone amongst menopausal women have been described. The postmenopausal women had reduced unbound clearance, reduced total clearance and increased half-life of prednisolone.
Product is not a new chemical entity therefore this section is not applicable.
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.