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Abiraterone

Also known as: Abiraterone Acetate

Description

Abiraterone acetate is converted in vivo to abiraterone, an androgen biosynthesis inhibitor. Specifically, abiraterone selectively inhibits the enzyme 17α-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in and is required for androgen biosynthesis in testicular, adrenal and prostatic tumour tissues. CYP17 inhibition also results in increased mineralocorticoid production by the adrenals.

ATC Classification

Code
Title
Category
L02BX03
Abiraterone
L Antineoplastic and immunomodulating agents → L02 Endocrine therapy → L02B Hormone antagonists and related agents → L02BX Other hormone antagonists and related agents

Trade names

Trade name
Countries

Singapore

United States

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Product Monographs

Monograph
Type
Country
ZYTIGA Film-coated tablet
MPI, EU: SmPC
UK