Abiraterone

Also known as: Abiraterone Acetate

Active ingredient description

Abiraterone acetate is converted in vivo to abiraterone, an androgen biosynthesis inhibitor. Specifically, abiraterone selectively inhibits the enzyme 17α-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in and is required for androgen biosynthesis in testicular, adrenal and prostatic tumour tissues. CYP17 inhibition also results in increased mineralocorticoid production by the adrenals.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
L02BX03
Abiraterone
L Antineoplastic and immunomodulating agents → L02 Endocrine therapy → L02B Hormone antagonists and related agents → L02BX Other hormone antagonists and related agents
Discover more medicines within L02BX03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
ZYTIGA Film-coated tablet
Summary of Product Characteristics (SPC)
UK
ZYTIGA Tablet
Summary of Product Characteristics (SPC)

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₄H₃₁NO
Molecular mass: 349.509 g/mol

External identifiers

CAS Substance: 154229-19-3
DrugBank Drug: DB05812
KEGG Drug: D09701
PubChem Compound: 132971
RxNorm Ingredient: 1100072
SNOMED-CT Concept: 699678007
Abiraterone (substance)
UNII Identifier: G819A456D0
ABIRATERONE

Medicines

Abiraterone is an active ingredient of these brands:

United States (US)

  • YONSA as ABIRATERONE ACETATE
  • ZYTIGA as ABIRATERONE ACETATE

Australia (AU)

  • ZYTIGA as ABIRATERONE ACETATE

Austria (AT)

  • ZYTIGA as ABIRATERONE ACETATE
  • (combination) AKEEGA as ABIRATERONE ACETATE

Brazil (BR)

Canada (CA)

  • ZYTIGA as ABIRATERONE ACETATE

Cyprus (CY)

  • ZYTIGA as ABIRATERONE ACETATE

Ecuador (EC)

Estonia (EE)

  • ZYTIGA as ABIRATERONE ACETATE

France (FR)

  • ZYTIGA as ABIRATERONE ACETATE
  • (combination) AKEEGA as ABIRATERONE ACETATE

Hong Kong (HK)

Ireland (IE)

  • ZYTIGA as ABIRATERONE ACETATE

Japan (JP)

  • ZYTIGA as ABIRATERONE ACETATE

Lithuania (LT)

  • TATICA as ABIRATERONE ACETATE
  • ZYTIGA as ABIRATERONE ACETATE
  • (combination) AKEEGA as ABIRATERONE ACETATE

Mexico (MX)

  • ZYTIGA as ABIRATERONE ACETATE

Netherlands (NL)

  • ZYTIGA as ABIRATERONE ACETATE

New Zealand (NZ)

  • YONSA as ABIRATERONE ACETATE
  • ZYTIGA as ABIRATERONE ACETATE

Nigeria (NG)

  • ZYTIGA as ABIRATERONE ACETATE

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

  • ZYTIGA as ABIRATERONE ACETATE

Tunisia (TN)

  • ZYTIGA as ABIRATERONE ACETATE

Turkey (TR)

United Kingdom (UK)

  • ZYTIGA as ABIRATERONE ACETATE

While we strive to include the brand names of medicines across all countries, our index remains incomplete. Therefore, it is possible that this medicine may also be marketed under different names in other countries.

 
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