Acetazolamide

Chemical formula: C₄H₆N₄O₃S₂  Molecular mass: 222.245 g/mol  PubChem compound: 1986

Therapeutic indications

Acetazolamide is indicated for:

Prophylaxis of mounting to high altitude

Population group: only adults (18 - 65 years old)

Acetazolamide is suitable for altitude sickness prevention and treatment. Acetazolamide is the superior drug for acute mountain sickness prevention due to its proven efficacy over the years in a large number of trials with an acceptable side-effect profile.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Congestive heart failure oedema, drug induced oedema

Population group: only adults (18 years old or older)

Acetazolamide is indicated in the treatment of congestive heart failure, drug-induced oedema.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Epilepsy

Population group: only adults (18 years old or older)

Acetazolamide is indicated for the treatment of epilepsy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Secondary or acute narrow angle glaucoma

Population group: only adults (18 years old or older)

Acetazolamide is an enzyme inhibitor which acts specifically on carbonic anhydrase. Acetazolamide is useful in glaucoma (chronic simple (open angle) glaucoma, secondary glaucoma and perioperatively in acute angle closure glaucoma where delay of surgery is desired in order to lower intraocular pressure) because it acts on inflow, decreasing the amount of aqueous secretion.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Chronic simple glaucoma (open angle)

Population group: only adults (18 years old or older)

Acetazolamide is an enzyme inhibitor which acts specifically on carbonic anhydrase. It is indicated in the treatment of glaucoma. Acetazolamide is useful in glaucoma (chronic simple (open angle) glaucoma, secondary glaucoma and perioperatively in acute angle closure glaucoma where delay of surgery is desired in order to lower intraocular pressure) because it acts on inflow, decreasing the amount of aqueous secretion.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Epilepsy

Population group: only minors (0 - 18 years old)

Acetazolamide is indicated for the treatment of epilepsy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Acetazolamide is contraindicated in the following cases:

Marked liver dysfunction

Hepatic failure stage IV

Marked renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Suprarenal gland failure

at least one of
Other and unspecified adrenocortical insufficiency
Primary adrenocortical insufficiency
Drug-induced adrenocortical insufficiency

Depressed levels of sodium

Hypo-osmolality and hyponatraemia

Depressed levels of potassium

Hypokalaemia

Hyper-chloremic acidosis

Metabolic acidosis, NAG, acidifying salts

Pregnancy

Pregnancy

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