Alitretinoin Other names: 9-cis-retinoic acid Alitretinoin

Chemical formula: C₂₀H₂₈O₂  Molecular mass: 300.435 g/mol  PubChem compound: 449171

Active ingredient description

Alitretinoin is a naturally-occurring endogenous hormone related to vitamin A, binds to and activates all known intracellular retinoid receptor subtypes (RAR, RAR, RAR, RXR, RXR, RXR). The efficacy of alitretinoin in treating KS lesions may be related to the demonstrated ability of alitretinoin to inhibit the in vitro growth of KS cells.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D11AH04 Alitretinoin D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AH Agents for dermatitis, excluding corticosteroids
Discover more medicines within D11AH04
L01XF02 Alitretinoin L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XF Retinoids for cancer treatment
Discover more medicines within L01XF02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
TOCTINO Capsule, soft Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
PANRETIN Gel European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 5300-03-8
DrugBank Drug: DB00523
KEGG Drug: D02815
PubChem Compound: 449171
RxNorm Ingredient: 81864
SNOMED-CT Concept: 116086005
Alitretinoin (substance)
UNII Identifier: 1UA8E65KDZ
ALITRETINOIN

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