Alitretinoin

Also known as: 9-cis-retinoic acid Alitretinoin

Active ingredient description

Alitretinoin is a naturally-occurring endogenous hormone related to vitamin A, binds to and activates all known intracellular retinoid receptor subtypes (RAR, RAR, RAR, RXR, RXR, RXR). The efficacy of alitretinoin in treating KS lesions may be related to the demonstrated ability of alitretinoin to inhibit the in vitro growth of KS cells.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
D11AH04
Alitretinoin
D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AH Agents for dermatitis, excluding corticosteroids
Discover more medicines within D11AH04
L01XF02
Alitretinoin
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XF Retinoids for cancer treatment
Discover more medicines within L01XF02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
TOCTINO Capsule, soft
Summary of Product Characteristics (SPC)
UK
PANRETIN Gel
Summary of Product Characteristics (SPC)

Medicines

Alitretinoin is the active ingredient of these drugs:

Drug
Countries
ALITRETAN

Austria

ALIZEM

France Netherlands

PANRETIN

Estonia Lithuania Poland United States

TOCTINO

Austria Canada Estonia Finland France

ZEMATANE

New Zealand

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₀H₂₈O₂
Molecular mass: 300.435 g/mol

External identifiers

CAS Substance: 5300-03-8
DrugBank Drug: DB00523
KEGG Drug: D02815
PubChem Compound: 449171
RxNorm Ingredient: 81864
SNOMED-CT Concept: 116086005
Alitretinoin (substance)
UNII Identifier: 1UA8E65KDZ
ALITRETINOIN
 
Next: Usage >