Amifampridine

Active ingredient description

Amifampridine blocks voltage-dependent potassium channels, thereby prolonging pre-synaptic cell membrane depolarisation. Prolonging the action potential enhances the transport of calcium into the nerve ending. The resulting increase in intra-cellular calcium concentrations facilitates exocytosis of acetylcholine-containing vesicles, which in turn enhances neuromuscular transmission.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
N07XX05
Amifampridine
N Nervous system → N07 Other nervous system drugs → N07X Other nervous system drugs → N07XX Other nervous system drugs
Discover more medicines within N07XX05

Medicines

Amifampridine is the active ingredient of these drugs:

Drug
Countries
FIRDAPSE

Austria Canada Estonia Finland France

RUZURGI

Canada United States

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
FIRDAPSE Tablet
Structured Product Labeling (SPL/PLR)
US
FIRDAPSE Tablet
Summary of Product Characteristics (SPC)

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

RU4S6E2G0J - AMIFAMPRIDINE

CAS registry number

54-96-6 - amifampridine

SNOMED-CT

782973004 - Amifampridine (substance)

 
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