Amifampridine

Chemical formula: C₅H₇N₃  Molecular mass: 109.132 g/mol  PubChem compound: 5918

Active ingredient description

Amifampridine blocks voltage-dependent potassium channels, thereby prolonging pre-synaptic cell membrane depolarisation. Prolonging the action potential enhances the transport of calcium into the nerve ending. The resulting increase in intra-cellular calcium concentrations facilitates exocytosis of acetylcholine-containing vesicles, which in turn enhances neuromuscular transmission.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
N07XX05 Amifampridine N Nervous system → N07 Other nervous system drugs → N07X Other nervous system drugs → N07XX Other nervous system drugs
Discover more medicines within N07XX05

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 FIRDAPSE Tablet MPI, US: SPL/PLR FDA, National Drug Code (US)
 FIRDAPSE Tablet MPI, EU: SmPC European Medicines Agency (EU)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 54-96-6
DrugBank Drug: DB11640
PubChem Compound: 5918
RxNorm Ingredient: 2106338
SNOMED-CT Concept: 782973004
Amifampridine (substance)
UNII Identifier: RU4S6E2G0J
AMIFAMPRIDINE

Medicines

Amifampridine is an active ingredient of these brands:

Austria (AT)

Canada (CA)

Croatia (HR)

Estonia (EE)

Finland (FI)

France (FR)

Ireland (IE)

Israel (IL)

Lithuania (LT)

Netherlands (NL)

Poland (PL)

United Kingdom (UK)

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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