Chemical formula: C₅H₇N₃ Molecular mass: 109.132 g/mol PubChem compound: 5918
Amifampridine blocks voltage-dependent potassium channels, thereby prolonging pre-synaptic cell membrane depolarisation. Prolonging the action potential enhances the transport of calcium into the nerve ending. The resulting increase in intra-cellular calcium concentrations facilitates exocytosis of acetylcholine-containing vesicles, which in turn enhances neuromuscular transmission.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
|N Nervous system → N07 Other nervous system drugs → N07X Other nervous system drugs → N07XX Other nervous system drugs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
|European Medicines Agency (EU)
|MPI, EU: SmPC
|FDA, National Drug Code (US)
|MPI, US: SPL/PLR
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