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Aminolevulinic acid

Description

5-Aminolevulinic acid (5-ALA) is a natural biochemical precursor of heme that is metabolised in a series of enzymatic reactions to fluorescent porphyrins, particularly PPIX. 5-ALA synthesis is regulated by an intracellular pool of free heme via a negative feedback mechanism. Administration of excess exogenous 5-ALA avoids the negative feedback control, and accumulation of PPIX occurs in target tissue. In the presence of visible light, fluorescence of PPIX (photodynamic effect) in certain target tissues can be used for photodynamic diagnosis.

ATC Classification

Code
Title
Category
L01XD04
Aminolevulinic acid
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XD Sensitizers used in photodynamic/radiation therapy

Trade names

Trade name
Countries

Austria Netherlands United Kingdom

Austria Spain United Kingdom United States

France

United States

Austria Cyprus France Netherlands Singapore

Product Monographs

Monograph
Type
Country
AMELUZ Gel
MPI, US: SPL/PLR
US
GLIOLAN Powder for oral solution
MPI, EU: SmPC