Aminolevulinic acid

Therapeutic indications

Aminolevulinic acid is indicated for:

Visualisation of malignant glioma

Irrespective of gender only Adults (18 years old or older)

5-Aminolevulinic acid is indicated in adult patients for visualisation of malignant tissue during surgery for malignant glioma (WHO grade III and IV).

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 20 mg/kg once


Active ingredient Aminolevulinic acid is contraindicated in the following cases:

Tetracyclines, sulfonamides, fluoroquinolones, hypericin extracts

After administration of this medicinal product, exposure of eyes and skin to strong light sources (e.g. operating illumination, direct sunlight or brightly focused indoor light) should be avoided for 24 hours. Co-administration with other potentially phototoxic substances (e.g. tetracyclines, sulfonamides, fluoroquinolones, hypericin extracts) should be avoided.


It is unknown whether 5-ALA or its metabolite protoporphyrin IX (PPIX) is excreted in human milk. The excretion of 5-ALA or PPIX in milk has not been studied in animals. Breast-feeding should be interrupted for 24 hours after treatment with this medicinal product.


There are no or limited amount of data from the use of 5-ALA in pregnant women. Some limited animal studies suggest an embryotoxic activity of 5-ALA plus light exposure. Therefore, 5-ALA should not be used during pregnancy.

Photosensitizing agent

Patients should not be exposed to any photosensitizing agent up to 2 weeks after administration of 5-aminolevulinic acid.


5-Aminolevulinic acid is contraindicated in acute or chronic types of porphyria.

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