Ciclosporin Other names: Cyclosporin A Cyclosporin

Chemical formula: C₆₂H₁₁₁N₁₁O₁₂  Molecular mass: 1,202.635 g/mol  PubChem compound: 5284373

Active ingredient description

Ciclosporin (also known as ciclosporin A) is a cyclic polypeptide immunomodulator with immunosuppressant properties. It has been shown to prolong survival of allogeneic transplants in animals and significantly improved graft survival in all types of solid organ transplantation in man. Ciclosporin has also been shown to have an anti-inflammatory effect.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L04AD01 Ciclosporin L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AD Calcineurin inhibitors
Discover more medicines within L04AD01
S01XA18 Ciclosporin S Sensory organs → S01 Ophthalmologicals → S01X Other ophthalmologicals → S01XA Other ophthalmologicals
Discover more medicines within S01XA18

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
IKERVIS Eye drops, emulsion European Medicines Agency (EU) MPI, EU: SmPC
SANDIMMUNE Capsule, Oral solution, Solution for injection FDA, National Drug Code (US) MPI, US: SPL/Old
NEORAL Oral solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 59865-13-3
DrugBank Drug: DB00091
KEGG Drug: D00184
PubChem Compound: 5284373
RxNorm Ingredient: 3008
SNOMED-CT Concept: 387467008
Ciclosporin (substance)
UNII Identifier: 83HN0GTJ6D
CYCLOSPORINE

Medicines

Ciclosporin is an active ingredient of these brands:

United States (US)

Australia (AU)

Cyprus (CY)

Finland (FI)

Germany (DE)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Romania (RO)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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