Chemical formula: C₂₅H₃₂ClFO₅ Molecular mass: 410.907 g/mol PubChem compound: 5311051
Administration of corticosteroids to pregnant animals can cause abnormalities of foetal development. There are no adequate and well-controlled studies of clobetasol propionate in pregnant women. Epidemiological studies in pregnant women following use of oral corticosteroids have indicated little or no risk with regard to an association with cleft palate. Limited evidence suggests a small risk for low birth weight when using large amounts of potent/very potent topical corticosteroids such as clobetasol propionate in pregnancy.
Clobetasol propionate cutaneous foam should not be used during pregnancy unless clearly necessary.
The safe use of clobetasol propionate during lactation has not been established. Glucocorticosteroids are excreted in breast milk, therefore clobetasol propionate cutaneous foam should not be used in breast-feeding women unless clearly necessary.
There are no data in humans to evaluate the effect of topical corticosteroids on fertility.
Clobetasol administered subcutaneously to rats decreased fertility in females at the highest dose.
No studies on the effects on the ability to drive and use machines have been performed.
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