Clobetasol propionate

Chemical formula: C₂₅H₃₂ClFO₅  Molecular mass: 410.907 g/mol  PubChem compound: 5311051

Active ingredient description

Clobetasol propionate, like other topical corticosteroids, has anti-inflammatory, antipruritic, and vasoconstrictive properties. Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D07AD01 Clobetasol D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AD Corticosteroids, very potent (group IV)
Discover more medicines within D07AD01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
CLARELUX Cutaneous foam Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
DERMOVATE Scalp application Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 25122-46-7
DrugBank Drug: DB11750
PubChem Compound: 5311051
RxNorm Ingredient: 2590
SNOMED-CT Concept: 32197004
Clobetasol propionate (substance)
SNOMED-CT Concept: 331854005
Clobetasol propionate (substance)
UNII Identifier: 779619577M
CLOBETASOL PROPIONATE
UNII Identifier: ADN79D536H
CLOBETASOL

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