Dimenhydrinate

Active ingredient description

Dimenhydrinate is a theoclate salt of the ethanolamine derivative diphenhydramine. It exhibits reversible competitive antagonism with histamine for the capture of H1 receptors. It has anticholinergic (antimuscarinic) properties that explain the anti-emetic action of the drug in cases of labyrinthial irritation (nausea, vertigo), and the central suppression it causes.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
R Respiratory system → R06 Antihistamines for systemic use → R06A Antihistamines for systemic use → R06AA Aminoalkyl ethers
Discover more medicines within R06AA11

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Structured Product Labeling (SPL)
US
Structured Product Labeling (SPL)
US

Medicines

Dimenhydrinate is the active ingredient of these drugs:

Drug
Countries

Ecuador

Turkey

Poland

Spain

Hong Kong

Hong Kong Spain

Hong Kong

Hong Kong

Hong Kong Singapore

Mexico

Hong Kong

Mexico

Brazil

Ecuador

Hong Kong

Hong Kong

Hong Kong

Canada

Hong Kong

Brazil

Hong Kong

Singapore

Hong Kong

Poland

Spain

Hong Kong Singapore

Ecuador

Hong Kong

Germany

Germany

Germany

Germany

Hong Kong

Austria Cyprus

Hong Kong

Austria Cyprus

Austria

Hong Kong

Germany

Germany

Singapore

Dimenhydrinate is also found within below combination drugs:

AIRMIT , ARLEVERT , ARTIGO , AVIOREXAN , AZALONUM , BIODRAMINA CAFEINA , CINFAMAR CAFEINA , DRAMAVIT B6 , DRAMIN B6 , DRAMIN B6 DL , EMET , HEMAREG B6 , MERCALM , NAUSICALM B6 , NAUSILON B6 , NORMOSTOP CAFEINA , PARAMMINE , SALDEVA , SALVARINA , SYMTIVER , TRAVEMATE , VERTIGIX , VERTIGO-VOMEX , VERTIROSAN VITAMIN B6

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₄H₂₈ClN₅O₃
Molecular mass: 469.97 g/mol

External identifiers

CAS Substance: 523-87-5
DrugBank Drug: DB00985
KEGG Drug: D00520
PubChem Compound: 10660
RxNorm Ingredient: 3444
SNOMED-CT Concept: 387469006
Dimenhydrinate (substance)
UNII Identifier: JB937PER5C
DIMENHYDRINATE