Dimenhydrinate

In co-administration of dimenhydrate with alcohol, the soothing effect of alcohol is enhanced. It is not recommended to drink alcohol with dimenhydrinate.

Dimenhydrate enhances the activity of central nervous system depressants, anticholinergics and MAO inhibitors.

Tricyclic antidepressants enhance the anticholinergic effects of dimenrigate.

Donepezil and dimenhydinate exhibit antagonistic activity.

Galantamine and dimenhydinate exhibit antagonistic activity.

Rivastigmine and dimenhydinate exhibit antagonistic activity.

Tacrine and dimenhydinate exhibit antagonistic activity.

Co-administration of trimethobenzamide with dimenhydinate may induce additional anticholinergic activity and enhance their undesirable, toxic effects.

Co-administration of triprolidine with dimenhydinate may lead to additional anticholinergic activity and to enhance their undesirable, toxic effects.

Concomitant administration of dimenhydinate and trospium may induce additional anticholinergic activity and enhance their undesirable, toxic effects.

Dimenhydrate should be administered with caution to the elderly and to people with hyperplasia of prostate, ocular hypertension, hyperthyroidism, epilepsy, cardiovascular disease, asthma, glaucoma.

The use of dimenhydrinate by women who are pregnant or may become pregnant requires that the potential benefits be weighed against the potential hazards. There are no adequate and well-controlled studies with dimenhydrinate in pregnant women. Reproduction studies in rats and rabbits using dimenhydrinate doses up to 20 and 25 times the human dose (mg/kg), respectively, have not revealed evidence of harm to the fetus or impaired fertility.

Small amounts of dimenhydrinate are excreted in breast milk. Because of the potential for adverse reactions in nursing infants from dimenhydrinate, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Before doing tasks that require special attention, wait until you know how you respond to dimenhydrinate. Dimenhydrinate may impair the ability to perform hazardous activities requiring mental alertness or physical coordination such as operating machinery or driving a car.

Drowsiness and dizziness are reported most frequently, particularly on high dosage. Pain may occur at the site of IM injection. Since dimenhydrinate contains 50% diphenhydramine, the possibility of diphenhydramine side effects must also be considered.

The following adverse reactions have also been reported:

Blood and lymphatic system disorders: anemia, thrombocytopenia, agranulocytosis, leukopenia, pancytopenia.

Body as a whole – general disorders: lassitude, fatigue, drug withdrawal syndrome, injection site inflammation.

Cardiac disorders: tachycardia, palpitations, hypotension, arrhythmia.

Ear and labyrinth disorders: tinnitus, labyrinthitis, vertigo.

Eye disorders: mydriasis, vision blurred, diplopia.

Gastrointestinal disorders: epigastric distress, nausea, dry mouth, constipation, diarrhea, vomiting

General disorders and administration site conditions: oedema.

Immune system disorders: hypersensitivity, anaphylactic reaction.

Metabolism and nutrition disorders: anorexia, decreased appetite.

Nervous system disorders: dizziness, headache, impaired coordination, somnolence, tremor, paraesthesia, ataxia, athetosis, convulsion, seizure, memory impairment, loss of consciousness.

Psychiatric disorders: depression, insomnia, hallucination, anxiety, confusional state, excitation, euphoric mood, nightmares, delirium, irritability, nervousness, restlessness, agitation.

Respiratory, thoracic, and mediastinal disorders: thickening of bronchial secretions, respiratory depression, dyspnoea.

Renal and urinary disorders: dysuria, urinary retention.

Skin and subcutaneous tissue disorders: angioedema, hyperhidrosis, rash, rash erythematous, rash maculopapular, pruritus, urticaria, fixed drug eruption, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiform, photosensitivity.

Vascular disorders: hypotension, hypertension, flushing.