Esketamine

Chemical formula: C₁₃H₁₆ClNO Molecular mass: 237.73 g/mol PubChem compound: 182137

Therapeutic indications

Esketamine is indicated for:

Treatment-resistant major depressive disorder

Population group: only adults (18 years old or older)

Esketamine, in combination with a SSRI or SNRI, is indicated for adults with treatment-resistant Major Depressive Disorder, who have not responded to at least two different treatments with antidepressants in the current moderate to severe depressive episode.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

56 mg starting dose on Day 1, 56 or 84 mg twice a week for Weeks 1-4, once a week for Weeks 5-8 and then every 2 weeks or once a week

28 mg starting dose on Day 1, 28 mg, 56 mg ή 84 mg twice a week for Weeks 1-4, once a week for Weeks 5-8 and then every 2 weeks or once a week

Acute short-term treatment of psychiatric emergency due to Major Depressive Disorder

Population group: only adults (18 - 65 years old)

Esketamine, co-administered with oral antidepressant therapy, is indicated in adults with a moderate to severe episode of Major Depressive Disorder, as acute short-term treatment, for the rapid reduction of depressive symptoms, which according to clinical judgement constitute a psychiatric emergency.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

84 mg twice per week for 4 weeks

Contraindications

Esketamine is contraindicated in the following cases:

Pregnancy

Lactation

Effects on ability to drive and use machines

Cardiovascular event, myocardial infarction (MI)

at least one of

Cardiovascular event
Myocardial infarction
Recent myocardial infarction

Intracerebral haemorrhage

Cerebral hemorrhage

Aneurysmal vascular disease

Aneurysm

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