Chemical formula: C₁₃H₁₆ClNO Molecular mass: 237.73 g/mol PubChem compound: 182137
Esketamine, the S-enantiomer of racemic ketamine, is a non-selective, non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor. Through NMDA receptor antagonism, esketamine produces a transient increase in glutamate release. Restoration of dopaminergic neurotransmission in brain regions involved in the reward and motivation, and decreased stimulation of brain regions involved in anhedonia, may contribute to the rapid response.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N01AX14 | Esketamine | N Nervous system → N01 Anesthetics → N01A Anesthetics, general → N01AX Other general anesthetics |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| SPRAVATO Nasal spray, solution | European Medicines Agency (EU) | MPI, EU: SmPC | |
| SPRAVATO Nasal spray, solution | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Esketamine is an active ingredient of these brands:
United States (US)
Austria (AT)Brazil (BR)
Canada (CA)
Cyprus (CY)
Ecuador (EC)
Estonia (EE)France (FR)
Hong Kong (HK)
Ireland (IE)
Israel (IL)
Italy (IT)
Lithuania (LT)
Netherlands (NL)New Zealand (NZ)
Poland (PL)
Romania (RO)
South Africa (ZA)
Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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