Estradiol Other names: Oestradiol

Chemical formula: C₁₈H₂₄O₂  Molecular mass: 272.382 g/mol  PubChem compound: 5757

Therapeutic indications

Estradiol is indicated for:

Indication

Population group: women, only adults (18 years old or older)

at least one of
Postmenopausal osteoporosis with pathological fracture
Postmenopausal osteoporosis
Menopausal and other perimenopausal disorders

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Atrophic vaginitis in menopause

Population group: only adults (18 - 65 years old)

Treatment for atrophic vaginitis, (due to oestrogen deficiency) in postmenopausal women.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Oestrogen deficiency symptoms in menopause

Population group: women, only adults (18 - 65 years old)

Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Vasomotor symptoms associated with the menopause

Population group: women, only adults (18 - 65 years old)

Estradiol is indicated in the treatment of moderate to severe vasomotor symptoms associated with the menopause.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Hypoestrogenism due to hypogonadism, castration, primary ovarian failure

Population group: only adults (18 - 65 years old)

Treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Androgen-dependent carcinoma of the prostate

Population group: only adults (18 - 65 years old)

Treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prevention of osteoporosis

Population group: only adults (18 - 65 years old)

When prescribing solely for the prevention of postmenopausal osteoporosis, therapy should only be considered for women at significant risk of osteoporosis and for whom non-estrogen medications are not considered to be appropriate.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Estradiol is contraindicated in the following cases:

Contraindication

at least one of
Malignant neoplasm of breast
Malignant neoplasms of female genital organs
Genitourinary tract hemorrhage
Lactation
Thromboembolic disorder
Cardiac failure
Pregnancy
Renal failure
Hepatic insufficiency
Hereditary erythropoietic porphyria
Porphyria cutanea tarda
Other porphyria

Pregnancy

Pregnancy

Lactation

Lactation

Porphyria

Porphyria

Oestrogen-dependent malignant tumours

Primary malignant neoplasm of endometrium

Genital bleeding

Genitourinary tract hemorrhage

Venous thromboembolism

at least one of
Thromboembolism of vein
Venous thrombosis
Pulmonary embolism

Thrombophilic disorders

Thrombophilia

Arterial thromboembolic disease, angina, myocardial infarction

at least one of
Arterial embolic and thrombotic occlusion
Angina
Myocardial infarction

Liver disease

at least one of
Hepatopathy
Hepatic insufficiency

Hypersensitivity to estradiol

Oestradiol allergy

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