Irbesartan

Chemical formula: C₂₅H₂₈N₆O  Molecular mass: 428.529 g/mol  PubChem compound: 3749

Active ingredient description

Irbesartan is a potent, orally active, selective angiotensin-II receptor (type AT1) antagonist. It is expected to block all actions of angiotensin-II mediated by the AT1 receptor, regardless of the source or route of synthesis of angiotensin-II. The selective antagonism of the angiotensin-II (AT1) receptors results in increases in plasma renin levels and angiotensin-II levels, and a decrease in plasma aldosterone concentration.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C09CA04 Irbesartan C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09C Angiotensin II antagonists, plain → C09CA Angiotensin II antagonists, plain
Discover more medicines within C09CA04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
APROVEL Tablet European Medicines Agency (EU) MPI, EU: SmPC
AVAPRO Film-coated tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 138402-11-6
DrugBank Drug: DB01029
KEGG Drug: D00523
PubChem Compound: 3749
RxNorm Ingredient: 83818
SNOMED-CT Concept: 386877005
Irbesartan (substance)
UNII Identifier: J0E2756Z7N
IRBESARTAN

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