Miconazole

Active ingredient description

Miconazole possesses an antifungal activity against the common dermatophytes and yeasts as well as an antibacterial activity against certain gram-positive bacilli and cocci. Its activity is based on the inhibition of the ergosterol biosynthesis in fungi and the change in the composition of the lipid components in the membrane, resulting in fungal cell necrosis.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Miconazole
A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment
Discover more medicines within A01AB09
Miconazole
A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AC Imidazole derivatives
Discover more medicines within A07AC01
Miconazole
D Dermatologicals → D01 Antifungals for dermatological use → D01A Antifungals for topical use → D01AC Imidazole and triazole derivatives
Discover more medicines within D01AC02
Miconazole
G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AF Imidazole derivatives
Discover more medicines within G01AF04
Miconazole
J Antiinfectives for systemic use → J02 Antimycotics for systemic use → J02A Antimycotics for systemic use → J02AB Imidazole derivatives
Discover more medicines within J02AB01
Miconazole
S Sensory organs → S02 Otologicals → S02A Antiinfectives → S02AA Antiinfectives
Discover more medicines within S02AA13

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)
UK
Summary of Product Characteristics (SPC)
UK
Summary of Product Characteristics (SPC)
UK
Summary of Product Characteristics (SPC)
UK

Medicines

Miconazole is the active ingredient of these drugs:

Drug
Countries

Ecuador

Cyprus Hong Kong Singapore

Germany

Brazil

Brazil

South Africa

Hong Kong

Australia Austria Brazil Cyprus Estonia

Brazil

Hong Kong New Zealand Singapore

Hong Kong

Spain

Singapore

Brazil

Brazil

Ecuador

South Africa

Cyprus Finland Ireland Mexico Netherlands

Hong Kong

Ecuador

Germany

South Africa

Ecuador

Estonia France

Canada Ecuador

Brazil

Brazil

Brazil

Tunisia

Germany

Ecuador

Brazil

Canada

New Zealand

Hong Kong

Singapore

Brazil

Canada

Singapore

Hong Kong

Tunisia

Hong Kong

United States

New Zealand

Hong Kong

South Africa

Hong Kong Singapore

Brazil

Brazil

Hong Kong Singapore

Miconazole is also found within below combination drugs:

ACCURE , ACNE PLUS , ACROMIZOL PLUS , AMPLIUM G , BEBEKTIN , BOSTON , BRENTAN , CANDIPLAS H , CARIDERMA , CLOTASODINE , CLOTASONE , CO-BETA-N , COLPOFILIN MAX , CREVAGIN , DAFRIN-H , DAKTACORT , DECOCORT , DERMIC , DERMOVAGIN , DOXIFEN , ELLAWON , ELOZART , EQUIFEM , EUGENCORT , FAMIDAL , FANGAN PLUS , FLURADERM , FUBETA , FUHARKIN , FUNGA-F , FUNGOCORT , FUOCORTE-F , GINECOPAST , GINEDAZOL , GINO-COLON , GYNOTRAN , HAVANDA , HYDRO-FUNGA , KENDERM , KENNETIC , KENOVAN , KLION-D , LONGAXON , MEDIVEL , MICOFEN PLUS , MICOSONE , MICREME H , MIKOTIN-NEO , MINAZOLE , MONICURE COMBO , MYCOSOLON , NEO PELVICILLIN , OTILAN , POTADERM-FORTE , PROHEALAN , RESOLVE PLUS , SIROLIN , SUFREXAL COMBI , TAIRO , TARA-PLUS , TETCOM , TINACORT , TOLNAZOLE , TRI-MICON , TRICOFEM , TRINIZOL-M , VOBADERM , VODADERM , VUSION , XATIM , ZARICORT

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₁₈H₁₄Cl₄N₂O
Molecular mass: 416.129 g/mol

External identifiers

CAS Substance: 22832-87-7
CAS Substance: 22916-47-8
DrugBank Drug: DB01110
KEGG Drug: D00882
PubChem Compound: 4189
RxNorm Ingredient: 6932
SNOMED-CT Concept: 372738006
Miconazole (substance)
UNII Identifier: 7NNO0D7S5M
MICONAZOLE