Naloxone

Chemical formula: C₁₉H₂₁NO₄ Molecular mass: 327.374 g/mol PubChem compound: 5284596

Therapeutic indications

Naloxone is indicated for:

Complete or partial reversal of central nervous system caused by opioids

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Complete or partial reversal of CNS and especially respiratory depression, caused by natural or synthetic opioids.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.1-0.2 mg and thereafter, if necessary, additional injections of 0.1 mg at 2 min intervals until satisfactory respiration and consciousness are obtained

0.01-0.02 mg/kg every 2-3 min until satisfactory respiration and consciousness are obtained

Suspected acute opioid overdose or intoxication

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

at least one of

Overdose of opiate
Opioid intoxication

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.01 mg/kg and thereafter, if satisfactory clinical response is not achieved, an additional injection of 0.1 mg/kg

0.4-2 mg and thereafter, if the desired clinical response is not achieved, repeat every 2-3 min up to a total dose of 10 mg

1 spray of 2 or 4 mg into one nostril and if the desired response is not obtained, repeat every 2-3 min

Reversal of respiratory and other CNS depression in the neonate whose mothers have received opioids

Population group: only newborns (0 - 40 days old)

Reversal of opiate activity

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.01 mg/kg and if the desired clinical response is not achieved, repeat every 2-3 min

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Naloxone

Therapeutic indications

Complete or partial reversal of central nervous system caused by opioids

0.1-0.2 mg and thereafter, if necessary, additional injections of 0.1 mg at 2 min intervals until satisfactory respiration and consciousness are obtained

0.01-0.02 mg/kg every 2-3 min until satisfactory respiration and consciousness are obtained

Suspected acute opioid overdose or intoxication

0.01 mg/kg and thereafter, if satisfactory clinical response is not achieved, an additional injection of 0.1 mg/kg

0.01 mg/kg and thereafter, if satisfactory clinical response is not achieved, an additional injection of 0.1 mg/kg

0.4-2 mg and thereafter, if the desired clinical response is not achieved, repeat every 2-3 min up to a total dose of 10 mg

0.4-2 mg and thereafter, if the desired clinical response is not achieved, repeat every 2-3 min up to a total dose of 10 mg

1 spray of 2 or 4 mg into one nostril and if the desired response is not obtained, repeat every 2-3 min

Reversal of respiratory and other CNS depression in the neonate whose mothers have received opioids

0.01 mg/kg and if the desired clinical response is not achieved, repeat every 2-3 min

0.01 mg/kg and if the desired clinical response is not achieved, repeat every 2-3 min

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