Chemical formula: C₁₉H₂₁NO₄ Molecular mass: 327.374 g/mol PubChem compound: 5284596
Naloxone hydrochloride, a semisynthetic morphine derivative (N-allyl-nor-oxymorphone), is a specific opioid antagonist that acts competitively at opioid receptors. It reveals very high affinity for the opioid receptor sites and therefore displaces both opioid agonists and partial antagonists, such as pentazocine, for example, but also nalorphine.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| V03AB15 | Naloxone | V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| NALOXONE Solution for injection/infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| NARCAN NALOXONE HCI | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Naloxone is an active ingredient of these brands:
United States (US)Australia (AU)Austria (AT)
Canada (CA)Croatia (HR)
Cyprus (CY)Estonia (EE)
Finland (FI)France (FR)Germany (DE)
Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)Lithuania (LT)
Malta (MT)
Netherlands (NL)New Zealand (NZ)Poland (PL)
Romania (RO)Singapore (SG)South Africa (ZA)Spain (ES)Turkey (TR)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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