Chemical formula: C₁₆H₂₄N₂O Molecular mass: 260.375 g/mol PubChem compound: 4636
Oximetazoline is an imidazoline derivative. It exhibits sympathomimetic activity and specifically stimulates the α-adrenergic receptors of the sympathetic system. When administered topically to the nose it causes vasoconstriction of the expansed arterioles of the mucosal nose and a concurrent reduction in blood flow. It also reduces the hypersecretion of the nasal mucosa, ultimately contributing to the decongestion of the nasal mucosa.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R01AA05 | Oxymetazoline | R Respiratory system → R01 Nasal preparations → R01A Decongestants and other nasal preparations for topical use → R01AA Sympathomimetics, plain |
| R01AB07 | Oxymetazoline | R Respiratory system → R01 Nasal preparations → R01A Decongestants and other nasal preparations for topical use → R01AB Sympathomimetics, combinations excl. corticosteroids |
| S01GA04 | Oxymetazoline | S Sensory organs → S01 Ophthalmologicals → S01G Decongestants and antiallergics → S01GA Sympathomimetics used as decongestants |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| BOOTS BLOCKED NOSE RELIEF Nasal spray | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Oxymetazoline is an active ingredient of these brands:
United States (US)Australia (AU)
Austria (AT)
Brazil (BR)Croatia (HR)
Estonia (EE)Finland (FI)
Hong Kong (HK)Ireland (IE)
Lithuania (LT)Malta (MT)
Netherlands (NL)
New Zealand (NZ)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)South Africa (ZA)
Spain (ES)
Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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