Promethazine

Chemical formula: C₁₇H₂₀N₂S Molecular mass: 284.419 g/mol PubChem compound: 4927

Therapeutic indications

Promethazine is indicated for:

Allergic rhinitis, urticaria, anaphylactic reactions to drugs

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

As symptomatic treatment for allergic conditions of the upper respiratory tract and skin including allergic rhinitis, urticaria and anaphylactic reactions to drugs and foreign proteins.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-100 mg

Nausea, vomiting

Population group: only adults (18 years old or older)

Active treatment of motion sickness.
Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

12.5-25 mg

Temporary disturbances of sleep pattern

Population group: only adults (18 years old or older)

As a night-time sleep aid, for the correction of temporary disturbances of sleep pattern where there is difficulty in going to sleep or staying asleep, caused for example by specific dislocation of normal routine.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

20 mg once

Allergic rhinitis, urticaria, anaphylactic reactions to drugs

Population group: only children (1 year - 12 years old)

As symptomatic treatment for allergic conditions of the upper respiratory tract and skin including allergic rhinitis, urticaria and anaphylactic reactions to drugs and foreign proteins.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

6.25-12.5 mg

Sedation

Population group: only adults (18 - 65 years old)

Preoperative, postoperative, and obstetric (during labor) sedation.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-50 mg once

Contraindications

Promethazine is contraindicated in the following cases:

MAOIs

Monoamine oxidase inhibitors (MAOIs)

Central nervous system depression

Central nervous system depression

Hypersensitivity to phenothiazines

Phenothiazine allergy

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