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ATC Group: A08AA Centrally acting antiobesity products

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A08
Antiobesity preparations, excl. diet products
3
A08A
Antiobesity preparations, excl. diet products
4
A08AA
Centrally acting antiobesity products

Contents

Code
Title
A08AA01
Phentermine
A08AA02
Fenfluramine
A08AA03
Amfepramone
A08AA04
Dexfenfluramine
A08AA05
Mazindol
A08AA06
Etilamfetamine
A08AA07
Cathine
A08AA08
Clobenzorex
A08AA09
Mefenorex
A08AA10
Sibutramine
A08AA11
Lorcaserin
A08AA56
Ephedrine, combinations
A08AA62
Bupropion and naltrexone

Active Ingredients

Chemical substance
Description
Clobenzorex

Clobenzorex is an N-substituted amphetamine analog that is converted to d-amphetamine soon after ingestion. Clobenzorex is a stimulant drug of the phenethylamine and amphetamine chemical classes used as an appetite suppressant.

Dexfenfluramine

Dexfenfluramine is the d-enantiomer of fenfluramine (structurally similar to amphetamine) and acts as a serotonergic anorectic drug that reduces appetite by increasing the amount of extracellular serotonin in the brain.

Lorcaserin

Lorcaserin is believed to decrease food consumption and promote satiety by selectively activating 5-HT2C receptors on anorexigenic pro-opiomelanocortin neurons located in the hypothalamus. The exact mechanism of action is not known. It is used as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adult patients.

Mazindol

Mazindol is a sympathomimetic amine for the treatment of obesity and Duchenne muscular dystrophy. Like other sympathomimetic appetite suppressants, mazindol is thought to act as a reuptake inhibitor of norepinephrine. In addition, it inhibits dopamine and serotonin reuptake. It stimulates the central nervous system, which increases heart rate and blood pressure, and decreases appetite.

Mefenorex

Mefenorex is an amphetamine derivative which was used as an appetite suppressant.

Phentermine
Sibutramine

Subitramine is a potent inhibitor of monoamines (serotonin, dopamine, noradrenaline) reuptake for the treatmen of obesity. Sibutramine is metabolized to metabolites M1 and M2 which are more active toward the monoamine transporters.

Monographs

Monograph
Type
Country
MYSIMBA Prolonged-release tablet
MPI, EU: SmPC