ATC Group: A08A Antiobesity preparations, excl. diet products
Anatomical Therapeutic Chemical Classification System
Clobenzorex is an N-substituted amphetamine analog that is converted to d-amphetamine soon after ingestion. Clobenzorex is a stimulant drug of the phenethylamine and amphetamine chemical classes used as an appetite suppressant.
Dexfenfluramine is the d-enantiomer of fenfluramine (structurally similar to amphetamine) and acts as a serotonergic anorectic drug that reduces appetite by increasing the amount of extracellular serotonin in the brain.
Lorcaserin is believed to decrease food consumption and promote satiety by selectively activating 5-HT2C receptors on anorexigenic pro-opiomelanocortin neurons located in the hypothalamus. The exact mechanism of action is not known. It is used as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adult patients.
Mazindol is a sympathomimetic amine for the treatment of obesity and Duchenne muscular dystrophy. Like other sympathomimetic appetite suppressants, mazindol is thought to act as a reuptake inhibitor of norepinephrine. In addition, it inhibits dopamine and serotonin reuptake. It stimulates the central nervous system, which increases heart rate and blood pressure, and decreases appetite.
Mefenorex is an amphetamine derivative which was used as an appetite suppressant.
Orlistat is a potent, specific and long-acting inhibitor of gastrointestinal lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine site of the gastric and pancreatic lipases. The inactivated enzyme is thus unavailable to hydrolyse dietary fat, in the form of triglycerides, into absorbable free fatty acids and monoglycerides.
Rimonabant is a selective cannabinoid-1 receptor (CB1) antagonist that inhibits the pharmacological effects of cannabinoid agonists in vitro and in vivo. The endocannabinoid system is a physiological system present in brain and peripheral tissues (including adipocytes) that affects energy balance, glucose and lipid metabolism and body weight, and in neurons of the mesolimbic system modulates the intake of highly palatable, sweet or fatty foods.
Subitramine is a potent inhibitor of monoamines (serotonin, dopamine, noradrenaline) reuptake for the treatmen of obesity. Sibutramine is metabolized to metabolites M1 and M2 which are more active toward the monoamine transporters.