ATC Group: L01CD Taxanes

Anatomical Therapeutic Chemical Classification System

Hierarchical position in ATC classification

Level
Code
Title
1
Antineoplastic and immunomodulating agents
2
Antineoplastic agents
3
Plant alkaloids and other natural products
4
L01CD
Taxanes

ATC group contents

Code
Title
Paclitaxel
Docetaxel
Paclitaxel poliglumex
Cabazitaxel
Paclitaxel and encequidar

Active ingredients

Active Ingredient
Description

Cabazitaxel is an antineoplastic agent that acts by disrupting the microtubular network in cells. Cabazitaxel binds to tubulin and promotes the assembly of tubulin into microtubules while simultaneously inhibiting their disassembly.

Docetaxel is an antineoplastic agent which acts by promoting the assembly of tubulin into stable microtubules and inhibits their disassembly which leads to a marked decrease of free tubulin.

Paclitaxel is an antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilises microtubules by preventing depolymerisation. This stability results in the inhibition of the normal dynamic reorganisation of the microtubule network that is essential for vital interphase and mitotic cellular functions.

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