ATC Group: R06AE Piperazine derivatives

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of R06AE in the ATC hierarchy

Level Code Title
1 R Respiratory system
2 R06 Antihistamines for systemic use
3 R06A Antihistamines for systemic use
4 R06AE Piperazine derivatives

Group R06AE contents

Code Title
R06AE01 Buclizine
R06AE03 Cyclizine
R06AE04 Chlorcyclizine
R06AE05 Meclozine
R06AE06 Oxatomide
R06AE07 Cetirizine
R06AE09 Levocetirizine
R06AE51 Buclizine, combinations
R06AE53 Cyclizine, combinations
R06AE55 Meclozine, combinations

Active ingredients in R06AE

Active Ingredient Description
Cetirizine

Cetirizine, a human metabolite of hydroxyzine, is a potent and selective antagonist of peripheral H1-receptors. In vitro receptor binding studies have shown no measurable affinity for other than Η1-receptors.

Chlorcyclizine
Cyclizine

Cyclizine is a histamine H1 receptor antagonist of the piperazine class which is characterised by a low incidence of drowsiness. It possesses anticholinergic and antiemetic properties. The exact mechanism by which cyclizine can prevent or suppress both nausea and vomiting from various causes is unknown.

Levocetirizine

Levocetirizine, the ® enantiomer of cetirizine, is a potent and selective antagonist of peripheral H1-receptors. Pharmacodynamic studies in healthy volunteers demonstrate that, at half the dose, levocetirizine has comparable activity to cetirizine, both in the skin and in the nose.

Meclozine

Meclizine is a first generation antihistamine that is used largely to treat vertigo and motion sickness.

Oxatomide

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