ICD-10 Specific code C83: Diffuse non-Hodgkin's lymphoma

Specific codes in ICD-10 are unique alphanumeric designations used to identify and categorize diseases, disorders, and conditions. They consist of 3-5 characters, including both letters and numbers, that provide a high level of detail and specificity.

Translations

Language Translation
Flag for English language  English Diffuse non-Hodgkin's lymphoma
Flag for French language  French Lymphome non folliculaire

Hierarchical position

Level Code Title
1 II Neoplasms
2 C00-C97 Malignant neoplasms
3 C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
4 C83 Diffuse non-Hodgkin's lymphoma

Contents

Code Title
C83.0 Non-Hodgkin's lymphoma: Small cell (diffuse)
C83.1 Non-Hodgkin's lymphoma: Small cleaved cell (diffuse)
C83.2 Non-Hodgkin's lymphoma: Mixed small and large cell (diffuse)
C83.3 Non-Hodgkin's lymphoma: Large cell (diffuse)
C83.4 Non-Hodgkin's lymphoma: Immunoblastic (diffuse)
C83.5 Non-Hodgkin's lymphoma: Lymphoblastic (diffuse)
C83.6 Non-Hodgkin's lymphoma: Undifferentiated (diffuse)
C83.7 Burkitt's tumour
C83.8 Other types of diffuse non-Hodgkin's lymphoma
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified

Indicated medicines

Active Ingredient Description
Bendamustine

Bendamustine is an alkylating antitumour agent with unique activity. The antineoplastic and cytocidal effect of bendamustine is based essentially on a cross-linking of DNA single and double strands by alkylation. As a result, DNA matrix functions and DNA synthesis and repair are impaired.

Chlorambucil

Chlorambucil is an aromatic nitrogen mustard derivative which acts as a bifunctional alkylating agent. In addition to interference with DNA replication, chlorambucil induces cellular apoptosis via the accumulation of cytosolic p53 and subsequent activation of an apoptosis promoter.

Cyclophosphamide

Cyclophosphamide has been demonstrated to have a cytostatic effect in many tumour types. The active metabolites of cyclophosphamide are alkylating agents which transfer alkyl groups to DNA during the process of cell division, thus preventing normal synthesis of DNA.

Etoposide

The main effect of etoposide appears to be at the late S and early G2 portion of the cell cycle in mammalian cells. The predominant macromolecular effect of etoposide seems to be the rupture of the double strand by an interaction with DNA-topoisomerase II or by the formation of free radicals. Etoposide has been shown to cause metaphase arrest in chick fibroblasts.

Ifosfamide

Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle.

Methylprednisolone

Methylprednisolone is a synthetic glucocorticoid and a methyl derivative of prednisolone. Methylprednisolone is a potent anti-inflammatory agent with the capacity to profoundly inhibit the immune system.

Prednisolone

Prednisolone is a glucocorticoid which has anti-inflammatory activity. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.

Vindesine

Vindesine is an antineoplastic agent derived from vinblastine, like the other vinca alkaloids it causes mitotic arrest in metaphase by binding to microtubular protein.