Source: Registered Drug Product Database (NG) Publisher: Applicant (MAH): ORANGE DRUGS LIMITED, 66/68 Town Planning Way, Ilupeju, Lagos, Nigeria, Phone.: +2348036005454, Email: eojukwu@orangegroups.com Manufactured by: PT. Dankos Farma, Jl. Rawa Gatel Blok III S, Kav. 36-38, Kawasan Industri Pulo Gadung, Jakarta 13930 - Indonesia
Paracetamol is a peripherally acting analgesic with antipyretic activity.
Caffeine acts on the central nervous system producing a condition of wakefulness and increased mental activity.
Paracetamol is rapidly and completely absorbed with peak plasma levels seen within 30 to 60 minutes. Less than 50% is protein bound and the drug is uniformly distributed throughout the body fluids.
Paracetamol is eliminated by metabolism to inactive conjugates followed by urinary excretion. The half life is 2.75-3.25 hours.
Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates.
Caffeine is readily absorbed after oral administration and is widely distributed throughout the body. Caffeine passes readily into the central nervous system and into saliva. In adults caffeine is metabolised almost completely via oxidation, demethylation and acetylation with only about 1% excreted unchanged. Elimination half life is about 3-6 hours in adults.
None stated.
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