PACOFEN Tablet Ref.[115136] Active ingredients: Caffeine Codeine Paracetamol

Source: Health Sciences Authority (SG)  Revision Year: 2023  Publisher: <u>Manufactured by:</u> Beacons Pharmaceuticals Pte. Ltd., No. 2, Second Chin Bee Road, Singapore 618769

Product name and form

Pacofen Tablets.

Pharmaceutical Form

Strawberry pink, 13.0 mm diameter, round, flat tablets.

Qualitative and quantitative composition

Paracetamol BP 500 mg/tab
Caffeine BP 30 mg/tab
Codeine phosphate BP 8 mg/tab

Active Ingredient

Caffeine is structurally related to the methylxanthines theophylline and theobromine. Caffeine’s main action is as a CNS stimulant.

Codeine is a centrally acting weak analgesic. Codeine exerts its effect through μ opioid receptors, although codeine has low affinity for these receptors, and its analgesic effect is due to its conversion to morphine. Codeine, particularly in combination with other analgesics such as paracetamol, has been shown to be effective in acute nociceptive pain. The anti-tussive activity of codeine is probably due to its depressant effect on the medullary cough centre in the brain.

Paracetamol is a medication used to treat pain and fever. It does appear to selectively inhibit COX activities in the brain, which may contribute to its ability to treat fever and pain.

List of Excipients

Pack sizes and marketing

PVDC/PVC Blisters with Aluminium Foil, blister packs of 10x10x10’s.

Marketing authorization holder

Manufactured by: Beacons Pharmaceuticals Pte. Ltd., No. 2, Second Chin Bee Road, Singapore 618769

Drugs

Drug Countries
PACOFEN Singapore, Turkey

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