Clotrimazole
Chemical formula: C₂₂H₁₇ClN₂ Molecular mass: 344.837 g/mol PubChem compound: 2812
Active ingredient description
Clotrimazole acts against fungi by inhibiting ergosterol synthesis. Inhibition of ergosterol synthesis leads to structural and functional impairment of the fungal cytoplasmic membrane. Clotrimazole has a broad antimycotic spectrum of action in vitro and in vivo, which includes dermatophytes, yeasts, moulds, etc.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| A01AB18 | Clotrimazole | A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment |
| D01AC01 | Clotrimazole | D Dermatologicals → D01 Antifungals for dermatological use → D01A Antifungals for topical use → D01AC Imidazole and triazole derivatives |
| G01AF02 | Clotrimazole | G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AF Imidazole derivatives |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| CLOTRIMADERM Vaginal cream | MPI, CA: SPM | Health Products and Food Branch (CA) | |
| CANESTEN BIFONAZOLE ONCE DAILY Cream | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| Canesten 100mg Pessary | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| CANESTEN THRUSH INTERNAL CREAM 10% w/w Vaginal cream | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
Medicines
Clotrimazole is an active ingredient of these brands:
Australia (AU)Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)Cyprus (CY)Ecuador (EC)
Estonia (EE)
Finland (FI)France (FR)Germany (DE)
Hong Kong (HK)
Ireland (IE)
Israel (IL)
Japan (JP)Lithuania (LT)Malta (MT)
Mexico (MX)Netherlands (NL)New Zealand (NZ)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)
South Africa (ZA)
Spain (ES)
Tunisia (TN)Turkey (TR)United Kingdom (UK)
United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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