Dexamethasone
Chemical formula: C₂₂H₂₉FO₅ Molecular mass: 392.461 g/mol PubChem compound: 5743
Active ingredient description
Dexamethasone is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. It has an approximately 7 times greater anti-inflammatory potency than prednisolone, another commonly prescribed corticosteroid. At high doses it reduces the immune response.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| A01AC02 | Dexamethasone | A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AC Corticosteroids for local oral treatment |
| C05AA09 | Dexamethasone | C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AA Corticosteroids |
| D07AB19 | Dexamethasone | D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AB Corticosteroids, moderately potent (group II) |
| D07XB05 | Dexamethasone | D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07X Corticosteroids, other combinations → D07XB Corticosteroids, moderately potent, other combinations |
| D10AA03 | Dexamethasone | D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AA Corticosteroids, combinations for treatment of acne |
| H02AB02 | Dexamethasone | H Systemic hormonal preparations, excl. Sex hormones and insulins → H02 Corticosteroids for systemic use → H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN → H02AB Glucocorticoids |
| R01AD03 | Dexamethasone | R Respiratory system → R01 Nasal preparations → R01A Decongestants and other nasal preparations for topical use → R01AD Corticosteroids |
| S01BA01 | Dexamethasone | S Sensory organs → S01 Ophthalmologicals → S01B Antiinflammatory agents → S01BA Corticosteroids, plain |
| S01CB01 | Dexamethasone | S Sensory organs → S01 Ophthalmologicals → S01C Antiinflammatory agents and antiinfectives in combination → S01CB Corticosteroids/antiinfectives/mydriatics in combination |
| S02BA06 | Dexamethasone | S Sensory organs → S02 Otologicals → S02B Corticosteroids → S02BA Corticosteroids |
| S03BA01 | Dexamethasone | S Sensory organs → S03 Ophthalmological and otological preparations → S03B Corticosteroids → S03BA Corticosteroids |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| DROPODEX Eye drops, solution | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| OZURDEX Intravitreal implant in applicator | MPI, EU: SmPC | European Medicines Agency (EU) | |
| DEXAMETHASONE Solution for injection | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| NEOFORDEX Tablet | MPI, EU: SmPC | European Medicines Agency (EU) |
Structural formula
3D molecular structure
External identifiers
Medicines
Dexamethasone is an active ingredient of these brands:
Albania (AL)
Australia (AU)
Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)
Cyprus (CY)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Ireland (IE)
Israel (IL)
Italy (IT)
Japan (JP)
Lithuania (LT)
Malta (MT)
Mexico (MX)
Netherlands (NL)
New Zealand (NZ)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)
South Africa (ZA)
Spain (ES)
Tunisia (TN)
Turkey (TR)
United Kingdom (UK)
United States (US)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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