Demorphan

Also known as: Demorphine Dextromethorphan Dextrometorphan Dextromorphan Dexyromethorphan Levomethorphan

Active ingredient description

Dextromethorphan is a non-opioid antitussive drug. The major metabolite of dextromethorphan, dextrorphan, binds with high affinity to σ-receptors to produce its antitussive activity without exhibiting the classic opiate effects that occur from binding into μ- and δ-receptors. In larger than therapeutic doses, dextrorphan is also an antagonist of N-methyl-D-aspartate (NMDA) receptors.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Dextromethorphan
R Respiratory system → R05 Cough and cold preparations → R05D Cough suppressants, excl. combinations with expectorants → R05DA Opium alkaloids and derivatives
Discover more medicines within R05DA09

Medicines

Demorphan is the active ingredient of these drugs:

Drug
Countries

Hong Kong

Hong Kong

Spain

Singapore

Spain

New Zealand

Spain

Hong Kong

Hong Kong Singapore

Hong Kong

Germany

France

Hong Kong

Hong Kong

Hong Kong

Hong Kong

Cyprus

Hong Kong

South Africa

Estonia

Hong Kong

Spain

Spain

Hong Kong

Spain

Canada

Spain

Cyprus

Hong Kong

Singapore

Estonia

France

Spain

Hong Kong Singapore

Spain

Tunisia

Spain

Tunisia

Spain

France

Hong Kong Singapore

Finland

Ireland New Zealand United Kingdom

Hong Kong

Germany

Hong Kong

Singapore

Austria

Poland

France Tunisia

Hong Kong Poland Singapore

Hong Kong Singapore

Poland

Austria

Demorphan is also found within below combination drugs:

ACTI-TRIN , ACTIFED DM COUGH , ACUGEST , AGRYPIN , AIDEX , ANTISSVES , AURIMEL , BARLODIN , BENYDEX , BENYPHED , BISOLVON ANTITUSIVO COMPOSITUM , BROMFED DM , BRONCO-DM , BRONCOMEDICAL , BRONPECT-D , CAMIDEX , CARNETTI , CEDINEX , CERATUSSIN , CHOLIGRIP NA NOC , CHUCO , CINFATOS COMPLEX , CINFATOS DESCONGESTIVO , CINFATOS EXPECTORANTE , CODOFEX , COLKOF-DAY , CONGESTED COLD & COUGH , COPHENDYL , COSYR , COUGHGRIP , DALERON COLD3 , DAMINE , DECOFEN , DEFETOL , DEGORAN L , DEGORAN T , DEMAZIN FLU , DEX-CO , DEXCOPHAN COUGH , DEXOHEXINE , DEXSIN , DEXTRO GG , DEXTRO PLUS , DEXTRODYL , DEXTROLAX , DHASEDYL , DIMETAPP DM COUGH & COLD , DIMETAPP EXTRA STRENGTH DM COUGH & COLD , EPHEDIN , EPHEDYL DM , EUROCOSYN , FETOCUS , FLU-MED , FLUCOR DAY , FLUSIMEX , FLUSIMEX NT , FRIOLGRIP , GRIPANAIT , GRIPBLOCKER EXPRESS , GRIPEX , GRYPOLEK , GRYPOSTOP , GUSILON COUGH , HISTALIX D.M. , HISTENOL II , INISTOLIN , KASON , KIDDYFLU , KOSYPHAN , LINCTODYL COUGH , LOTUSSIN , MARSEDYL , MARUSEN , MEDIFED , MEDOFED COMPOUND , MENDICOF , METHON-S , METHOPIME , METHORSEDYL , METOFEN COMPOUND , METOPLEX , MUCINEX MULTI-ACTION COLD FLU AND SORE THROAT , MUCOLEXIN , MUCUS AND PHLEGM RELIEF WITH COUGH CONTROL , NEOCITRAN EXTRA STRENGTH TOTAL COLD , NEOCITRAN ULTRA STRENGTH TOTAL FLU , NEOCITRAN ULTRA STRENGTH TOTAL FLU NIGHT , NITECALL , NUEDEXTA , OKALTUS , OPINASIN , ORNACOL , PADEVIX , PAEDICOF , PHARMATUSGRIP , PRADASON , PRESCO , PRODEX , PROPALGINA PLUS , REMIDOL , ROBITUSSIN DM , RONDOFEN DM , SEDILIX , SINUCLEAR COUGH , SUNTUSS , SUPERPLEX , SUPERPLEX COUGH , SYNBRON COUGH , TARAFEN , TARVONIL , TEMPIER , THERAFLU ND , THERAFLU NT , TRIAMINIC DAY TIME COLD & COUGH , TUSELIN , TUSSIC , TUSSIN DM , UNI-COLEX DM , UNI-FEDRA DM , VICKS MEDINITE , VINCITOS , WASEDYL , WICK MEDINAIT

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)
UK
Summary of Product Characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

7355X3ROTS - DEXTROMETHORPHAN

CAS registry number

125-71-3 - dextromethorphan

SNOMED-CT

387114001 - Dextromethorphan (substance)