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ATC Group: J01A Tetracyclines

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
J
Antiinfectives for systemic use
2
J01
Antibacterials for systemic use
3
J01A
Tetracyclines

Contents

Code
Title
J01AA
Tetracyclines

Active Ingredients

Chemical substance
Description
Chlortetracycline

Chlortetracycline is a tetracycline antibiotic isolated from Streptomyces aureofaciens. It has a role as an antiprotozoal drug, a fluorescent probe, a calcium ionophore and an antibacterial drug.

Clomocycline
Demeclocycline

Tetracyclines have a broad spectrum of anti-microbial activity and act by interfering with bacterial protein synthesis. They are active against a large number of gram positive and gram negative pathogenic bacteria, including some which are resistant to penicillin.

Doxycycline

Doxycycline is primarily bacteriostatic and is believed to exert its antimicrobial effect by the inhibition of protein synthesis.

Metacycline
Minocycline

Minocycline is a semi-synthetic derivative of tetracycline. Minocycline inhibits protein synthesis in susceptible bacteria. In common with other tetracyclines it is primarily bacteriostatic and has a similar spectrum of activity to other tetracyclines.

Omadacycline

Omadacycline is an antibacterial drug. It should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

Oxytetracycline

Oxytetracycline is a broad spectrum tetracycline antibiotic with activity against a large number of gram positive and gram negative bacteria. The product acts by interfering with bacterial protein synthesis.

Rolitetracycline
Sarecycline

Sarecycline is a narrow-spectrum tetracycline-class antibiotic indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older.

Tetracycline

Tetracyclines are taken up into sensitive bacterial cells by an active transport process. Once within the cell they bind reversibly to the 30S subunit of the ribosome, preventing the binding of aminoacyl transfer RNA and inhibiting protein synthesis and hence cell growth.

Tigecycline

Tigecycline, a glycylcycline antibiotic, inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome. This prevents incorporation of amino acid residues into elongating peptide chains.

Monographs

Monograph
Type
Country
DORYX MPC Tablet
MPI, US: SPL/PLR
US
EFRACEA Modified-release hard capsule
MPI, EU: SmPC
UK
TYGACIIL Powder for solution for infusion
MPI, EU: SmPC
XERAVA Powder for solution for injection
MPI, US: SPL/PLR
US