ATC Group: M01AE Propionic acid derivatives

Anatomical Therapeutic Chemical Classification System

Hierarchical position in ATC classification

Level
Code
Title
1
Musculo-skeletal system
2
Antiinflammatory and antirheumatic products
3
Antiinflammatory and antirheumatic products, non-steroids
4
M01AE
Propionic acid derivatives

ATC group contents

Code
Title
Ibuprofen
Naproxen
Ketoprofen
Fenoprofen
Fenbufen
Benoxaprofen
Suprofen
Pirprofen
Flurbiprofen
Indoprofen
Tiaprofenic acid
Oxaprozin
Ibuproxam
Dexibuprofen
Flunoxaprofen
Alminoprofen
Dexketoprofen
Naproxcinod
Ibuprofen, combinations
Naproxen and esomeprazole
Ketoprofen, combinations
Naproxen and misoprostol

Active ingredients

Active Ingredient
Description

Dexibuprofen (= S(+)-ibuprofen) is considered to be the pharmacologically active enantiomer of racemic ibuprofen. Racemic ibuprofen is a non-steroidal substance with antiinflammatory and analgesic effects. Its mechanism of action is thought to be due to inhibition of prostaglandin synthesis.

Dexketoprofen belongs to the non-steroidal anti-inflammatory group of drugs. The mechanism of action of Dexketoprofen is related to the reduction of prostaglandin synthesis by the inhibition of cyclooxygenase pathway. Furthermore, the inhibition of the synthesis of prostaglandins could affect other inflammation mediators such as kinins, causing an indirect action which would be additional to the direct action.

Fernoprofen has analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of prostaglandin synthesis. Its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Flurbiprofen is a propionic acid derivative NSAID which acts through inhibition of prostaglandin synthesis. In humans flurbiprofen has potent analgesic, antipyretic and anti-inflammatory properties.

Ibuprofen is a propionic acid derivative NSAID that has demonstrated its efficacy by inhibition of prostaglandin synthesis. In humans ibuprofen reduces inflammatory pain, swellings and fever. Furthermore, ibuprofen reversibly inhibits platelet aggregation.

Ketoprofen is a non-steroidal anti-inflammatory drug. It has anti-inflammatory and analgesic actions.

Naproxen is a non-steroidal anti-inflammatory analgesic compound with antipyretic properties as has been demonstrated in classical animal test systems. Naproxen exhibits its anti-inflammatory effect even in adrenalectomised animals, indicating that its action is not mediated through the pituitary-adrenal axis.

Oxaprozin has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of oxaprozin, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, especially arthritic pain. Results of in-vitro experiments and ex-vivo studies suggest a neutral or possibly beneficial effect of tiaprofenic acid on joint cartilage under experimental conditions.

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